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Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles
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1.
1. J. E. Kennedy, Nat. Rev. Cancer 5(4), 321 (2005).
http://dx.doi.org/10.1038/nrc1591
2.
2. L. A. Crum, M. Bailey, J. H. Hwang, V. Khokhlova, and O. Sapozhnikov, Phys. Procedia 3(1), 25 (2010).
http://dx.doi.org/10.1016/j.phpro.2010.01.005
3.
3. J. E. Kennedy, F. Wu, G. R. ter Haar, F. V. Gleeson, R. R. Phillips, M. R. Middleton, and D. Cranston, Ultrasonics 42, 931 (2004).
http://dx.doi.org/10.1016/j.ultras.2004.01.089
4.
4. C. J. Diederich, Int. J. Hyperthermia 21(8), 745 (2005).
http://dx.doi.org/10.1080/02656730500271692
5.
5. J. Hwang, S. Vaezy, R. Martin, M. Cho, M. Noble, L. Crum, M. Kimmey, Gastrointestinal. Endoscopy, 58(1), 111 (2003).
http://dx.doi.org/10.1067/mge.2003.322
6.
6. H. G. Zhang, K. Mehta, P. Cohen, and C. Guha, Cancer Lett. 271(2), 191 (2008).
http://dx.doi.org/10.1016/j.canlet.2008.05.026
7.
7. S. Wang, V. Zderic, and V. Frenkel, Future Oncol. 6(9), 1497 (2010).
http://dx.doi.org/10.2217/fon.10.101
8.
8. E. L. Jones, L. R. Prosnitz, M. W. Dewhirst, P. K. Marcom, P. H. Hardenbergh, L. B. Marks, D. M. Brizel, and Z. Vujaskovic, Clin. Cancer Res. 10(13), 4287 (2004).
http://dx.doi.org/10.1158/1078-0432.CCR-04-0133
9.
9. C. W. Song, H. J. Park, C. K. Lee, and R. Griffin, Int. J. Hyperthermia 21(8), 761 (2005).
http://dx.doi.org/10.1080/02656730500204487
10.
10. E. Guilhon, P. Voisin, J. de Zwart, B. Quesson, R. Salomir, C. Maurange, V. Bouchaud, P. Smirnov, H. de Verneuil, A. Vekris, P. Canioni, and C. Moonen, J. Gene Med. 5(4), 333 (2003).
http://dx.doi.org/10.1002/jgm.345
11.
11. S. Dromi, V. Frenkel, A. Luk, B. Traughber, M. Angstadt, M. Bur, J. Poff, J. Xie, S. Libutti, K. Li, and B. Wood, Clin. Cancer Res. 13(9), 2722 (2007).
http://dx.doi.org/10.1158/1078-0432.CCR-06-2443
12.
12. E. A. Filonenko and V. A. Khohlova, Acoust. Phys. 47, 468 (2001).
http://dx.doi.org/10.1134/1.1385422
13.
13. J. Huang, R. Holt, R. Cleveland, and R. Roy, J. Acoust. Soc. Am. 116, 2451 (2004).
http://dx.doi.org/10.1121/1.1787124
14.
14. H. Pennes, J. Appl. Phys. 1, 93 (1948).
15.
15. S. Vaezy, M. Andrew, P. Kaczkowski, and L. Crum, Annu. Rev. Biomed. Eng. 3, 375 (2001).
http://dx.doi.org/10.1146/annurev.bioeng.3.1.375
16.
16. K. J. Henle and L. A. Dethlefsen, Annu. N.Y. Acad. Sci. 335, 234 (1980).
http://dx.doi.org/10.1111/j.1749-6632.1980.tb50752.x
17.
17. S. Sapareto, L. Hopwood, W. Dewey, M. Raju, and J. Gray, Cancer Res. 38, 393 (1978).
18.
18. D. Bate and W. J. Mackillop, Br. J. Cancer 62, 183 (1990).
http://dx.doi.org/10.1038/bjc.1990.257
19.
19. G. Kong, R. D. Braun, and M. W. Dewhirst, Cancer Res. 61, 3027 (2001).
20.
20. M. Solovchuk, T. Sheu, W. Lin, I. Kuo, and M. Thiriet, Int. J. Heat Mass Transfer 55, 1261 (2012).
http://dx.doi.org/10.1016/j.ijheatmasstransfer.2011.09.023
21.
21. See supplementary material at http://dx.doi.org/10.1063/1.4754113 for “Ultrasound Exposure System” and “Animal Anesthesia”. [Supplementary Material]
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/content/aip/journal/apl/101/12/10.1063/1.4754113
2012-09-18
2014-09-16

Abstract

High intensity focused ultrasound (HIFU)-induced hyperthermia is a promising tool for cancer therapy. Three-dimensional nonlinear acoustic-bioheat transfer-blood flow-coupling model simulations and in vivothermocouplemeasurements were performed to study hyperthermia effects in rabbit auricular vein exposed to pulsed HIFU (pHIFU) at varied duty cycles (DCs). pHIFU-induced temperature elevations are shown to increase with increasing DC. A critical DC of 6.9% is estimated for temperature at distal vessel wall exceeding 44 °C, although different tissue depths and inclusions could affect the DC threshold. The results demonstrate clinic potentials of achieving controllable hyperthermia by adjusting pHIFU DCs, while minimizing perivascular thermal injury.

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Scitation: Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles
http://aip.metastore.ingenta.com/content/aip/journal/apl/101/12/10.1063/1.4754113
10.1063/1.4754113
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