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Neuronal alignment on asymmetric textured surfaces
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View: Figures


Image of FIG. 1.
FIG. 1.

(a) Top: Schematics of the growth cone adhesion to the asymmetric nanotextured surface, where β is the angle of the tilted nanorods. The axons extend preferentially in a direction opposite to the direction of the tilted nanorods. The direction of growth is defined as the reference direction (i.e., the 0 radians direction) for the analysis presented in the paper. Fluorescence (middle) and bright field (bottom) images of two different cells growing on the surface are also shown. The length of the axon shown in the figure is 60 microns. (b) Scanning electron microscopy (top) and atomic force microscope (bottom) image of the surface.

Image of FIG. 2.
FIG. 2.

(a) The direction of axon is shown in a schematic as the direction opposite to the direction of the nanotextured surface. Angular distributions for neural growth at (b) glass surface (control), (c) 2000 cells/cm2, (d) 6000 cells/cm2, and (e) 25 000 cells/cm2. All angles are measured with respect to this direction. All plots on (c)-(e) are on the same vertical scale. The bins at π radians for each histogram shown in the middle column collect axon counts from the bins at π and −π of the corresponding histogram shown in third column. The data show weaker preferential growth in the direction of the nanotextured surface (θ = π) than in the opposite direction (θ = 0). Solid lines in the right hand column histograms represent theoretical fits using a model of Brownian motion in constant field.

Image of FIG. 3.
FIG. 3.

Ensembles of 100 trajectories generated from a biased, symmetric (δ = κ = 0) and asymmetric random walk for various values of bias parameter κ and azimuthal anisotropy parameter δ. Starting points are indicated with white circles.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Neuronal alignment on asymmetric textured surfaces