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Microbubble array for on-chip worm processing
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View: Figures


Image of FIG. 1.
FIG. 1.

(a) Experimental setup. (b) The image at t = 0 s depicts that no worms are trapped prior to the application of voltage. (c) As can be seen at t = 30 s, the incoming worms in the flow are trapped.

Image of FIG. 2.
FIG. 2.

(Top left) Trapping efficiency shows a decreasing trend with an increasing flow rate, whereas enrichment shows an increasing trend with increasing flow rate (top right). (Bottom) Temporal monitoring of C. elegans at first bubble column at a flow rate of 0.14 ml/min indicating saturation.

Image of FIG. 3.
FIG. 3.

(a) shows both big and small C. elegans trapped at the bubble at 190V (b) upon reduction of voltage to 100 V the bigger worm escapes leaving behind the smaller worm (c) the smaller worm ultimately escapes when the voltage is further reduced to 67 V. (Bottom) The graph shows a relationship between the size of the C. elegans and the threshold voltage at which the worms escape the bubble trap.

Image of FIG. 4.
FIG. 4.

The SRF and the worm propulsive force are plotted a function of the worm length. A fitting parameter, bubble oscillation amplitude, is used to calculate the SRF. Respectively, SRF 1, 2, 3 are based on 8, 5, 2 μm of bubble oscillation amplitude.

Image of FIG. 5.
FIG. 5.

A single C. elegans was manipulated to travel along a square loop by turning the acoustic field on and off with proper timing control.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Microbubble array for on-chip worm processing