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Interaction and diffusion of gold nanoparticles in bovine serum albumin solutions
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Image of FIG. 1.
FIG. 1.

Normalized autocorrelation curves for AuNP (R = 2.5 nm) diffusing in BSA solution in phosphate buffer at various protein concentrations. Solid lines are fit to the curves using Eq. (2) . Arrow shows direction of increasing concentration.

Image of FIG. 2.
FIG. 2.

Diffusion coefficient of R = 2.5 nm AuNPs as a function of protein concentration. The inset shows the measured diffusion for 5 and 10 nm AuNPs at higher concentrations of BSA. Also shown (stars) viscosity as a function of BSA concentration.

Image of FIG. 3.
FIG. 3.

Hydrodynamic radii of NPs plotted as a function of BSA concentration. Red solid line represents fit of anticooperative binding model, and blue dashed line shows comparison to Langmuir binding isotherm fitted to first and last 30% of data points. The conversion of concentration units is as follows: [BSA] = [BSA] × M × 10, where M is the molecular weight of BSA and is equal to 66 430 g/mol. The inset shows K as a function of the hydrodynamic radius R.


Generic image for table
Table I.

Translational diffusion coefficient (D) of AuNPs obtained by autocorrelation analysis, and hydrodynamic radius (R) calculated using SE relation in absence and presence of BSA.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Interaction and diffusion of gold nanoparticles in bovine serum albumin solutions