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(a) The SERS spectrum of the cancerous esophageal tissue section with Ag colloid. (b) The Raman spectrum of cancerous esophageal tissue section without Ag colloid.
(a) Mean SERS spectrum of the esophageal cancer tissue sample (red line, n = 44). (b) Mean SERS spectrum of the normal tissue sample (black line, n = 44) and (c) the difference spectrum [i.e., cancer-normal]. The shaded areas represent the standard deviations of the means.
(a) A three-dimensional scatter plots of the first principal component (PC1) and second principal component (PC2) versus the fourth principal component (PC4) for the esophageal cancer group (red triangle) and the normal group (black circle). (b) The receiver operating characteristic (ROC) curve of the discrimination result for using PCA-LDA-based SERS spectral classification with leave-one-out, cross-validation procedure. The integrated area under the ROC curve was 0.99.
SERS peak positions and tentative vibrational mode assignments (ν—stretching vibration; δ—bending vibration).
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