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Esophageal cancer detection based on tissue surface-enhanced Raman spectroscopy and multivariate analysis
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10.1063/1.4789996
/content/aip/journal/apl/102/4/10.1063/1.4789996
http://aip.metastore.ingenta.com/content/aip/journal/apl/102/4/10.1063/1.4789996

Figures

Image of FIG. 1.
FIG. 1.

(a) The SERS spectrum of the cancerous esophageal tissue section with Ag colloid. (b) The Raman spectrum of cancerous esophageal tissue section without Ag colloid.

Image of FIG. 2.
FIG. 2.

(a) Mean SERS spectrum of the esophageal cancer tissue sample (red line, n = 44). (b) Mean SERS spectrum of the normal tissue sample (black line, n = 44) and (c) the difference spectrum [i.e., cancer-normal]. The shaded areas represent the standard deviations of the means.

Image of FIG. 3.
FIG. 3.

(a) A three-dimensional scatter plots of the first principal component (PC1) and second principal component (PC2) versus the fourth principal component (PC4) for the esophageal cancer group (red triangle) and the normal group (black circle). (b) The receiver operating characteristic (ROC) curve of the discrimination result for using PCA-LDA-based SERS spectral classification with leave-one-out, cross-validation procedure. The integrated area under the ROC curve was 0.99.

Tables

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Table I.

SERS peak positions and tentative vibrational mode assignments (ν—stretching vibration; δ—bending vibration).

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/content/aip/journal/apl/102/4/10.1063/1.4789996
2013-01-29
2014-04-24
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Esophageal cancer detection based on tissue surface-enhanced Raman spectroscopy and multivariate analysis
http://aip.metastore.ingenta.com/content/aip/journal/apl/102/4/10.1063/1.4789996
10.1063/1.4789996
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