Skip to main content

News about Scitation

In December 2016 Scitation will launch with a new design, enhanced navigation and a much improved user experience.

To ensure a smooth transition, from today, we are temporarily stopping new account registration and single article purchases. If you already have an account you can continue to use the site as normal.

For help or more information please visit our FAQs.

banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
1. M. S. Kim, T. Kim, S.-Y. Kong, S. Kwon, C. Y. Bae, J. Choi, C. H. Kim, E. S. Lee, and J.-K. Park, “ Breast cancer diagnosis using a microfluidic multiplexed immunohistochemistry platform,” PLoS ONE 5, e10441 (2010).
2. D. Chen, W. Du, Y. Liu, W. Liu, A. Kuznetsov, F. E. Mendez, L. H. Philipson, and R. F. Ismagilov, “ The chemistrode: A droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution,” Proc. Natl. Acad. Sci. 105, 1684316848 (2008).
3. A. Ainla, G. D. M. Jeffries, R. Brune, O. Orwar, and A. Jesorka, “ A multifunctional pipette,” Lab Chip 12, 1255 (2012).
4. A. J. You, R. J. Jackman, G. M. Whitesides, and S. L. Schreiber, “ A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells,” Chem. Biol. 4, 969975 (1997).
5. G. V. Kaigala, R. D. Lovchik, U. Drechsler, and E. Delamarche, “ A vertical microfluidic probe,” Langmuir 27, 56865693 (2011).
6. D. Juncker, H. Schmid, and E. Delamarche, “ Multipurpose microfluidic probe,” Nat. Mater. 4, 622628 (2005).
7. G. V. Kaigala, R. D. Lovchik, and E. Delamarche, “ Microfluidics in the ‘open space’ for performing localized chemistry on biological interfaces,” Angew. Chem., Int. Ed. 51, 1122411240 (2012).
8. G. Taylor, “ Dispersion of soluble matter in solvent flowing slowly through a tube,” Proc. R. Soc. London, Ser. A 219, 186203 (1953).
9. M. T. Kreutzer, A. Günther, and K. F. Jensen, “ Sample dispersion for segmented flow in microchannels with rectangular cross section,” Anal. Chem. 80, 15581567 (2008).
10. J. G. Kralj, H. R. Sahoo, and K. F. Jensen, “ Integrated continuous microfluidic liquid–liquid extraction,” Lab Chip 7, 256263 (2007).
11. A. Günther, S. A. Khan, M. Thalmann, F. Trachsel, and K. F. Jensen, “ Transport and reaction in microscale segmented gas–liquid flow,” Lab Chip 4, 278286 (2004).
12. X. Niu, F. Gielen, J. B. Edel, and A. J. deMello, “ A microdroplet dilutor for high-throughput screening,” Nat. Chem. 3, 437442 (2011).
13. G. Takei, M. Nonogi, A. Hibara, T. Kitamori, and H.-B. Kim, “ Tuning microchannel wettability and fabrication of multiple-step Laplace valves,” Lab Chip 7, 596602 (2007).
14. T. Zhang and T. Cui, “ Tunable wetting properties of patterned silicon microchannels with varied surface free energy based on layer-by-layer nano self-assembly,” J. Micromech. Microeng. 21, 045015 (2011).
15. M. Eichler, K. Nagel, P. Hennecke, and C.-P. Klages, “ Area-selective microplasma treatment in microfluidic channels for novel fluid phase separators,” Plasma Process. Polym. 9, 11601167 (2012).
16. C. N. Baroud, F. Gallaire, and R. Dangla, “ Dynamics of microfluidic droplets,” Lab Chip 10, 20322045 (2010).
17. P.-G. De Gennes, F. Brochard-Wyart, and D. Quéré, Capillarity and Wetting Phenomena: Drops, Bubbles, Pearls, Waves ( Springer, 2002).
18. J. Berthier, F. Loe-Mie, V.-M. Tran, S. Schoumacker, F. Mittler, G. Marchand, and N. Sarrut, “ On the pinning of interfaces on micropillar edges,” J. Colloid Interface Sci. 338, 296303 (2009).

Data & Media loading...


Article metrics loading...



Microfluidic probes (MFPs) are a class of non-contact, scanning microfluidic devices that hydrodynamically confine nanoliter volumes of a processing liquid on a surface immersed in another liquid. So far only chemical processes using a single processing liquid have been implemented using MFPs. In this letter, we present the design and implementation of a probe head that allows segmented two-phase flows to be used, which will enable different chemical species to be sequentially delivered to a surface in defined volumes and concentrations. Central to this probe head is a spacer-removal module comprising blocking pillars in the injection channel, a bypass and an orifice leading to the aspiration channel. We present a capillarity-based analytical model that provides insight into the functionality of the module based on geometrical parameters. In addition, we study the difference between two- and three-channel modules and predict a reduction in fluctuation of the footprint of the confined liquid for the three-channel module. We show that such a module with a pillar spacing, a orifice width, and an oblique angle of can remove immiscible spacers (Fluorinert FC-40) from an aqueous flow at a rate of up to 15 spacers per second while maintaining hydrodynamic confinement of processing liquid.


Full text loading...


Access Key

  • FFree Content
  • OAOpen Access Content
  • SSubscribed Content
  • TFree Trial Content
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd