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High-extinction virtually imaged phased array-based Brillouin spectroscopy of turbid biological media
R. D. Hartschuh, A. Kisliuk, V. Novikov, A. P. Sokolov, P. R. Heyliger, C. M. Flannery, W. L. Johnson, C. L. Soles, and W.-L. Wu, Appl. Phys. Lett. 87(17), 173121 (2005);
J. R. Sandercock, RCA Rev. 36(1), 89 (1975).
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Brillouin microscopy has recently emerged as a powerful technique to characterize the mechanical properties of biological tissue, cell, and biomaterials. However, the potential of Brillouin microscopy is currently limited to transparent samples, because Brillouinspectrometers do not have sufficient spectralextinction to reject the predominant non-Brillouin scattered light of turbid media. To overcome this issue, we combined a multi-pass Fabry-Perot interferometer with a two-stage virtually imaged phased array spectrometer. The Fabry-Perotetalon acts as an ultra-narrow band-pass filter for Brillouin light with high spectralextinction and low loss. We report background-free Brillouinspectra from Intralipid solutions and up to 100 μm deep within chicken muscle tissue.
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