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Two-dimensional hydrodynamic flow focusing in a microfluidic platform featuring a monolithic integrated glass micronozzle
M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. C. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, Nat. Biotechnol. 23, 83 (2005).
A. Wolff, I. R. Perch-Nielsen, U. D. Larsen, P. Friis, G. Goranovic, C. R. Poulsen, J. P. Kutter, and P. Telleman, Lab Chip 3, 22 (2003).
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Two-dimensional hydrodynamic flow focusing is demonstrated through a microfluidic device featuring a monolithic integrated glass micronozzle inside a flow-focusing geometry. Such a coaxial configuration allows simple one-step focusing of a sample fluid stream, jetted from the micronozzle tip, in both in-plane and out-of-plane directions. The width of the focused filament can be precisely controlled and further scaled down to the submicrometer regime to facilitate rapid hydrodynamic
mixing. Fluorescence quenching experiments reveal ultra-fast microsecond mixing of the denaturant into the focused filament. This device offers new possibilities to a set of applications such as the study of protein folding kinetics.
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