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Adaptive optical biocompact disk for molecular recognition
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10.1063/1.1915511
/content/aip/journal/apl/86/18/10.1063/1.1915511
http://aip.metastore.ingenta.com/content/aip/journal/apl/86/18/10.1063/1.1915511
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

The AO-BioCD disk and probe geometry that converts a periodic pattern of printed protein on a spinning disk into a high-frequency phase modulation. The figure shows the adaptive BioCD layout (bottom), the probing scheme (top-right), and fluorescence photo of the protein pattern (top-left).

Image of FIG. 2.
FIG. 2.

The AO-BioCD calibration. (a) The homodyne signal spectrum of printed BSA. Insert: the atomic force microscope scan of the edge of one BSA spoke. (b) The homodyne signal spectrum of the phase modulator, driven by a 5 MHz ac voltage with , which generates a phase modulation of for an equivalent optical thickness of 2.8 nm.

Image of FIG. 3.
FIG. 3.

The AO-BioCD Immunoassay results. (a) Single-analyte experiment detecting specific binding between mouse IgG and anti-mouse IgG. Tracks B and C are incubated with specific antibody, showing positive detection. (b) Two-analyte experiment detecting specific bindings between mouse IgG (rabbit IgG) and anti-mouse IgG (anti-rabbit IgG). Tracks B and C were incubated with rabbit, and C and D were incubated with mouse antibody. The overlapping detection in Track C cancels out.

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/content/aip/journal/apl/86/18/10.1063/1.1915511
2005-04-28
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Adaptive optical biocompact disk for molecular recognition
http://aip.metastore.ingenta.com/content/aip/journal/apl/86/18/10.1063/1.1915511
10.1063/1.1915511
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