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Specific and efficient adsorption of phosphorothioated DNA on Au-based surfaces and electrodes
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10.1063/1.2800383
/content/aip/journal/apl/91/17/10.1063/1.2800383
http://aip.metastore.ingenta.com/content/aip/journal/apl/91/17/10.1063/1.2800383
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Figures

Image of FIG. 1.
FIG. 1.

(Color online) (a) AFM image of PT poly(dG)-poly(dC) DNA on mica. (b) Schematic presentation of PT poly(dG)-poly(dC) molecule. S atoms of the G-strand backbone are marked in red. (c) Cross section of one of the molecules, marked in the image.

Image of FIG. 2.
FIG. 2.

(Color online) (a) AFM image of PT poly(dG)-poly(dC) DNA on Au surface. (b) Enlargement of part of (a), demonstrating high density of the molecules. (c) AFM image of poly(dG)-poly(dC) DNA on Au surface, where single molecules are occasionally observed. The concentrations of molecules in solution is , and length is 3000 base pairs. Inset: Single molecules connected to the surface through thiols at their ends.

Image of FIG. 3.
FIG. 3.

(Color online) Analysis of the surface densities of PT poly(dG)-poly(dC) and poly(dG)-poly(dC) molecules as a function of their concentration in solution.

Image of FIG. 4.
FIG. 4.

(Color online) (a) PT poly(dG)-poly(dC) deposited between Au–Pd electrodes on substrate. Many molecules are attached to the electrodes and hardly observed elsewhere. The electrodes appear bright due to the contrast used to enhance the molecule appearance. Scale bar: . (b) Poly(dG)-poly(dC) deposited on a similar electrode set. The small number of observed molecules (marked) compared to (a) is clear and striking. In this case, the washing after deposition was gentle. Scale bar: .

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/content/aip/journal/apl/91/17/10.1063/1.2800383
2007-10-22
2014-04-20
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Specific and efficient adsorption of phosphorothioated DNA on Au-based surfaces and electrodes
http://aip.metastore.ingenta.com/content/aip/journal/apl/91/17/10.1063/1.2800383
10.1063/1.2800383
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