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Illustration of the flow direction in the nanochannel, in the nanoslit area and finally ending in the microchannel. The left scheme represents cross sections of the nanoslit and the microchannel (not to scale). The flow lines expand laterally in the nanoslit area.
Finite element simulation of the lateral distance of dispersion as a function of the diffusion coefficient for different values of the input pressures (i.e., flow velocities). Increased diffusion coefficient decreases the lateral dispersion.
Video images showing the diffusion of fluorescent species through the nanochannel, the nanoslit, and the microchannel. We push WGA proteins in the nanochannel and applied no flow at the output microchannel in case (a), and a flow of several nl/min in case (b). The flow in the output microchannel increases the flow in the nanochannel by aspiration effect and increases the dispersion in the nanoslit. Proteins (WGA, ) are replaced with fluorescein (FITC, ) in cases (c) and (d) under same conditions as (a) and (b).
1D pressure-driven flow through the nanochannel. The pushing pressure is and the flow linear speed (advance of the fluorescent front) in the nanochannel is about .
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