Mechanism and sensitivity of the intrinsic charge detection of biomolecular interactions by field effect devices
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(Color online) Combined measurements of the and the electrolyte concentration sensitivity and allow for the determination of (a) the surface potential , (b) the total surface charge , (c) the sensitivity toward binding analyte charge and (d) the interdependency of all sensitivities. and are normalized to the Nernstian responses, the surface charge is normalized to , and the charge sensitivity is normalized to the maximum sensitivity . For surfaces with the electrolyte concentration response is negative, and graphs (a)–(c) are mirrored at the -sensitivity axis. For illustration the surface equipotential lines are drawn in (d).
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