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Micromechanical observation of the kinetics of biomolecular interactions
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10.1063/1.3006329
/content/aip/journal/apl/93/17/10.1063/1.3006329
http://aip.metastore.ingenta.com/content/aip/journal/apl/93/17/10.1063/1.3006329
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Schematic illustration of experimental setup for in situ real-time monitoring of biomolecular interactions in liquid environment. The inset provides the SEM image of piezoelectric thick film microcantilever, whose dimension is .

Image of FIG. 2.
FIG. 2.

In situ resonant frequency shift induced by CRP antigen-antibody interactions (with CRP antigen concentration of 100 ng/ml). Inset displays the fluorescence image of CRP antigen-antibody binding on the cantilever’s surface.

Image of FIG. 3.
FIG. 3.

In situ resonant frequency shift driven by immobilization of ssDNA and/or dsDNA in the TE buffer solution.

Image of FIG. 4.
FIG. 4.

In situ resonant frequency shift driven by immobilization of ssDNA (probe) as well as hybridization between probe ssDNA and target ssDNA. The inset displays a fluorescence image of hybridized DNA molecules on the cantilever’s surface.

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/content/aip/journal/apl/93/17/10.1063/1.3006329
2008-10-31
2014-04-21
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Micromechanical observation of the kinetics of biomolecular interactions
http://aip.metastore.ingenta.com/content/aip/journal/apl/93/17/10.1063/1.3006329
10.1063/1.3006329
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