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A microscale multi-inlet vortex nanoprecipitation reactor: Turbulence measurement and simulation
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10.1063/1.3125428
/content/aip/journal/apl/94/20/10.1063/1.3125428
http://aip.metastore.ingenta.com/content/aip/journal/apl/94/20/10.1063/1.3125428
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Illustration of MIVR applied to Flash NanoPrecipitation. Drug and polymers are dissolved in solvent and injected to mix with nonsolvent to create supersaturation and therefore precipitate the particles. Protected nanoparticles are obtained after the stabilization by copolymer self-assembly.

Image of FIG. 2.
FIG. 2.

Schematic diagram of micro PIV setup. The reactor was illuminated by a dual pulse Nd:YAG laser and images were captured using a microscope and CCD camera. The images was divided into small interrogation windows and vectors were calculated by correlating two images taken at different times.

Image of FIG. 3.
FIG. 3.

Velocity profile comparison of microPIV and CFD at . Data extracted from mid-height of the reactor are represented by △, quarter-top plane: ◻, quarter-bottom plane: ◇; simulation data at corresponding locations are represented by a solid line (mid-plane), dashed line (quarter-top), and dotted line (quarter-bottom).

Image of FIG. 4.
FIG. 4.

Velocity profile comparison of microPIV and CFD at . The symbol description is same as in Fig. 3.

Image of FIG. 5.
FIG. 5.

Velocity profile and 2D TKE comparison of microPIV and CFD at . The symbol description is same as in Fig. 3.

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/content/aip/journal/apl/94/20/10.1063/1.3125428
2009-05-21
2014-04-23
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: A microscale multi-inlet vortex nanoprecipitation reactor: Turbulence measurement and simulation
http://aip.metastore.ingenta.com/content/aip/journal/apl/94/20/10.1063/1.3125428
10.1063/1.3125428
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