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Integrated nanostructures for direct detection of DNA at attomolar concentrations
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10.1063/1.3226103
/content/aip/journal/apl/95/14/10.1063/1.3226103
http://aip.metastore.ingenta.com/content/aip/journal/apl/95/14/10.1063/1.3226103
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Figures

Image of FIG. 1.
FIG. 1.

(a) Schematic representation of the photolithographically defined chip (b) Scanning electron microscopy (SEM) image showing aperture before (left) and after (right) template-directed electrodeposition. Scale bar represents . (c) SEM image (top) and the electrochemical response (bottom) of four electrodes on the same chip. (d) Schematic illustrating the electrocatalytic reporter system.

Image of FIG. 2.
FIG. 2.

(a) Schematic illustration and differential pulse voltammetry measurements representing hybridization with a DNA probe (top) versus a PNA probe (bottom). (b) Signal to background ratio comparison of a DNA modified device and a PNA modified device. (c) Signal to background ratio comparison of PNA devices having different MCH spacer concentrations.

Image of FIG. 3.
FIG. 3.

(a) Signal to background ratio of a PNA device (left) and a DNA device (right) at different concentrations of complementary target. The system noise associated with hybridization with noncomplementary target is shown for reference. The devices contained MCH acting as a spacer. (b) Sequences of the nucleic acid targets and probes used herein.

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/content/aip/journal/apl/95/14/10.1063/1.3226103
2009-10-05
2014-04-17
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Integrated nanostructures for direct detection of DNA at attomolar concentrations
http://aip.metastore.ingenta.com/content/aip/journal/apl/95/14/10.1063/1.3226103
10.1063/1.3226103
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