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Soluble state high resolution atomic force microscopy study of Alzheimer’s -amyloid oligomers
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View: Figures


Image of FIG. 1.
FIG. 1.

A model showing the sequence of schematic assembly of monomers which can lead to the formation of oligomers (dimers, tetramers, 12 mers, etc., and fibrils).

Image of FIG. 2.
FIG. 2.

(a) Tapping mode image (in liquid) of APTES coated mica control sample showing featureless and uniform surface and (b) surface topography of oligomers taken using conventional SiN cantilever having pyramidal probes. Background noise and surface corrugation is dominant in the image.

Image of FIG. 3.
FIG. 3.

(a) Liquid tapping mode image of oligomers acquired in solution of ADDLs in F12 solution. AFM examination of toxic ADDLs shows small globular structures approximately 2–4 nm in height and a distinct lack of fibrils. (b) Depicts cross-sectional profile.

Image of FIG. 4.
FIG. 4.

(a) High resolution liquid tapping mode images of monomers and oligomers. The molecule heights are in the range from 0.5–1 nm. For these images, the solution was imaged at a concentration of . (b) Section profile where the height of these monomers is around 0.5–1 nm.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Soluble state high resolution atomic force microscopy study of Alzheimer’s β-amyloid oligomers