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A model showing the sequence of schematic assembly of monomers which can lead to the formation of oligomers (dimers, tetramers, 12 mers, etc., and fibrils).
(a) Tapping mode image (in liquid) of APTES coated mica control sample showing featureless and uniform surface and (b) surface topography of oligomers taken using conventional SiN cantilever having pyramidal probes. Background noise and surface corrugation is dominant in the image.
(a) Liquid tapping mode image of oligomers acquired in solution of ADDLs in F12 solution. AFM examination of toxic ADDLs shows small globular structures approximately 2–4 nm in height and a distinct lack of fibrils. (b) Depicts cross-sectional profile.
(a) High resolution liquid tapping mode images of monomers and oligomers. The molecule heights are in the range from 0.5–1 nm. For these images, the solution was imaged at a concentration of . (b) Section profile where the height of these monomers is around 0.5–1 nm.
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