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Schematics showing reporter sequence carrying the gold nanoparticle (yellow star) binding to the hairpin probe after complementary DNA (PC-target, red) interacts with the loop (green) of the hairpin. The PC-target starts with GGCAA and covers the whole loop. Black portion depicts the part of hairpin that formed the stem before opening.
Comparison of data for a representative nanogap before hybridization of PC-target and probe (circles) and after exposure and hybridization of probe to PC-DNA and GNP-reporter (triangles). Insets: Left image shows chip with --reporter. Right image shows chip with --reporter. The inset to right micrograph shows the details of GNP-reporter payload on bare silicon chips (scale bar: ).
SEM micrographs of nanoelectrode chips show side by side comparison of the amount of GNP in case of MM-target (left) and PC-target (right). There is a distinct difference in the GNP densities. Inset to right image shows closeup images of GNPs bridging the gap between the nanoelectrodes, causing the increase in conductivity for PC-target (scale bar: ).
DNA sequences and their modifications.
Count of average number of GNPs on silicon surfaces.
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