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Electrical detection of single-base DNA mutation using functionalized nanoparticles
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Image of FIG. 1.
FIG. 1.

Schematics showing reporter sequence carrying the gold nanoparticle (yellow star) binding to the hairpin probe after complementary DNA (PC-target, red) interacts with the loop (green) of the hairpin. The PC-target starts with GGCAA and covers the whole loop. Black portion depicts the part of hairpin that formed the stem before opening.

Image of FIG. 2.
FIG. 2.

Comparison of data for a representative nanogap before hybridization of PC-target and probe (circles) and after exposure and hybridization of probe to PC-DNA and GNP-reporter (triangles). Insets: Left image shows chip with --reporter. Right image shows chip with --reporter. The inset to right micrograph shows the details of GNP-reporter payload on bare silicon chips (scale bar: ).

Image of FIG. 3.
FIG. 3.

SEM micrographs of nanoelectrode chips show side by side comparison of the amount of GNP in case of MM-target (left) and PC-target (right). There is a distinct difference in the GNP densities. Inset to right image shows closeup images of GNPs bridging the gap between the nanoelectrodes, causing the increase in conductivity for PC-target (scale bar: ).


Generic image for table
Table I.

DNA sequences and their modifications.

Generic image for table
Table II.

Count of average number of GNPs on silicon surfaces.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Electrical detection of single-base DNA mutation using functionalized nanoparticles