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Schematic view of a cell spreading on an ECM. The filaments are connected with the ligand integrin. (a) In the initial spreading phase, the geometry of the spreading cell is approximated as a spherical cap without lamellipodium. (b) In the fast continuous spreading phase, a thin lamellipodial sheet of thickness forms isotropically in the contact frontier.
Contact radius vs time in log-log plots in the initial spreading regime. The theoretical curve agrees well with the experimental data (circles) obtained by Cuvelier et al. (Ref. 8), where we take for HeLa cell/fibronectin substrate and for biotinylated red blood cell/streptavidin substrate in the insert (Ref. 8).
The increasing contact radius vs time in the fast spreading regime of cell spreading. The theoretical results (solid lines) fit well with experimental measurements (dots). The circles are adapted from the experiments of Döbereiner et al. (Ref. 4), where and ; the triangles are from Dubin-Thaler et al. (Ref. 3), where and ; and the squares are from Giannone et al. (Ref. 1), where and .
The increasing contact radius with time under several representative values of ECM stiffness and bond density . The experimental data are adapted from the experiments of Döbereiner et al. (Ref. 4), and we use the same parameters as in Fig. 3.
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