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DNA oxidation by singlet delta oxygen produced by atmospheric pressure microdischarges
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10.1063/1.3499362
/content/aip/journal/apl/97/14/10.1063/1.3499362
http://aip.metastore.ingenta.com/content/aip/journal/apl/97/14/10.1063/1.3499362
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Schematic representation of the experimental setup. For simplicity, the electrical circuits were drawn for only one MCSD.

Image of FIG. 2.
FIG. 2.

Evolution, vs the current per discharge, of the SDO density obtained in the afterglow, at 30 cm downstream from the last MCSD, at atmospheric pressure in a mixture, with and NO partial pressures, respectively, equal to 37.4 mbars and 0.4 mbars, and a He flow of 10 ln/min, for different number of active MCSD: inverted , , , and .

Image of FIG. 3.
FIG. 3.

Evolution, vs the total flow, of the SDO density obtained at atmospheric pressure by running an array of 4 MCSD at 3 mA per discharge in a mixture, with and NO partial pressures, respectively, equal to 10.0 mbars and 0.2 mbars, when there is no solution in the interaction cell, and for different downstream distances: and .

Image of FIG. 4.
FIG. 4.

Evolution, for the discharge conditions of Fig. 3 with a He flow of 8 ln/min, and vs the time of interaction between SDO in gas phase and dGuo in solution, of the concentration of the main dGuo degradation products: (spiroiminodihydantoin -deoxyribonucleoside), (2,2-diamino-5-[2-deoxy--D-erythro-pentofuranosylamino]-5(2H)-oxazolone), and (4-hydroxy-8-oxo-4,8-dihydro--deoxyguanosine).

Image of FIG. 5.
FIG. 5.

Evolution, vs the SDO molecules reaching the DNA–SDO interaction cell during given times of oxidation, of the 4-OH-8-oxodGuo concentration resulting from the degradation of different aqueous solutions of dGuo: , and .

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/content/aip/journal/apl/97/14/10.1063/1.3499362
2010-10-06
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: DNA oxidation by singlet delta oxygen produced by atmospheric pressure microdischarges
http://aip.metastore.ingenta.com/content/aip/journal/apl/97/14/10.1063/1.3499362
10.1063/1.3499362
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