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(a) Schematic diagram of a unit microwell with hydrodynamic guiding structures for a high capturing efficiency, (b) illustration of fabrication procedures, (c) photograph of the fabricated microwell array chip and the magnified view of four microwells, (d) four microwell structures with various channel length ratios of path A and path B.
(a) Estimated capturing efficiencies as a function of channel width and channel length ratios and (b) COMSOL simulation results of flow velocity distribution and streamlines. (The inserted bar indicates velocity profiles at an injecting flow speed of 1 mm/s and the white lines are velocity streamlines).
(a) Capturing efficiency vs length ratio when a channel width ratio is 2.5 (error bar represents its standard deviation, ). (b) Photograph of captured single green-fluorescence-activated PC3 cells in microwell array. Only one PC3 cell was captured at each capturing site. In the image, 39 microwells are occupied with single cells out of 42 microwells, (d) and (e) Single cell culture for three days: photographs were taken in an identical microwell at day 0 (c) and day 3 (d).
Dimension of path A and path B.
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