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Mesoporous silica nanoparticles encapsulating as a highly efficient magnetic resonance imaging contrast agent
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View: Figures


Image of FIG. 1.
FIG. 1.

(a) Supercell structure of . The unit cell is marked out at the top-left of the supercell. Key: Si, yellow; O, red; H, white; and Gd, green. (b) HRTEM image of synthesized nanoparticles with a Gd doping. The inset at the top-right is the magnified micrograph marked out with red line to guide reader’s eye; the inset at the bottom-right is the EDS of the synthesized nanoparticles.

Image of FIG. 2.
FIG. 2.

The small angle XRD patterns of both simulated model and synthesized nanoparticles.

Image of FIG. 3.
FIG. 3.

(a) Water-adsorptive isostherms of different assembled models at 298 K with a varying pressure from 10 to 20 kPa. (b) The averages of simulated water adsorption of different assembled models. (c) The water adsorption of synthesized nanoparticles measured at 298 K with saturation pressure.

Image of FIG. 4.
FIG. 4.

The percentage of water molecules adsorbed on the surface of cluster vs the total water molecules adsorbed by at 298 K with different pressures from 20 to 120 kPa. Inset: snapshots of water molecules adsorbed in a unit cell of at 298 K with 20 and 120 kPa. Key: Si, yellow; O, red; H, white; and Gd, green.

Image of FIG. 5.
FIG. 5.

The TEM images of liver (a) and tumor tissue (b) of nude mouse injected with nanoparticles.

Image of FIG. 6.
FIG. 6.

The in vivo MR images of NPC CNE-2 xenografted tumor and inferior vena cava in nude mice before (a) and after 15 min (b) the venous injection of nanoparticles. The tumor and inferior vena cava are marked with the arrow 1 and 2, respectively.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Mesoporous silica nanoparticles encapsulating Gd2O3 as a highly efficient magnetic resonance imaging contrast agent