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(Color online) (a) Normalized absorption spectra of PEG-GNRs, blood, and blood plus PEG-GNRs. Inset: a typical TEM image of the PEG-GNRs. (b) PA signal intensity of the tumor region after PEG-GNRs injection in vivo. Results are a summary of three independent experiments.
(Color online) X-ray images of a mouse before injection (a), 5 min (b), 90 min (c), and 300 min (d) after injection of PEG-GNRs. (e) Time-dependent average x-ray signal intensity ratio between tumor region and normal tissue region (T/N ratio).
(Color online) Noninvasive PA imaging of a tumor in vivo employing PEG-GNRs. PA image acquired before injection (a), 5 min (b), and 90 (c) min after injection of PEG-GNRs. (d) Differential image obtained by subtracting the preinjection image (Fig. 3(a)) from the post-injection image (Fig. 3(b)). (e) Reconstruction profile of image (a) (black line) and image (b) (red dash line) at the position indicated by dashed lines.
(Color online) Combined x-ray and PA images of a mouse tumor in vivo. (a) Overlay of x-ray image and PA image. (b) Enlargement of corresponding image area highlighted by a square in panel (a).
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