Skip to main content

News about Scitation

In December 2016 Scitation will launch with a new design, enhanced navigation and a much improved user experience.

To ensure a smooth transition, from today, we are temporarily stopping new account registration and single article purchases. If you already have an account you can continue to use the site as normal.

For help or more information please visit our FAQs.

banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
1.P. Fratzl, Collagen Structure and Mechanics (Springer Science+Bussiness Media, 2008).
2.S. E. Calvin and M. L. Oyen, “Microstructure and mechanics of the chorioamnion membrane with an emphasis on fracture properties,” Ann. N. Y. Acad. Sci. 1101, 16685 (2007).
3.M. L. Oyen, R. F. Cook, T. Stylianopoulos, V. H. Barocas, S. E. Calvin, and D. V. Landers, “Uniaxial and biaxial mechanical behavior of human amnion,” J. Mater. Res. 20(11), 29022909 (2005).
4.J. A. Burdick and G. D. Prestwich, “Hyaluronic acid hydrogels for biomedical applications,” Adv. Mater. 23(12), H41H56 (2011).
5.K. Tonsomboon, C. T. Koh, and M. L. Oyen, “Time-dependent fracture toughness of cornea,” J. Mech. Behav. Biomed. Mater. 34, 116123 (2014).
6.U. Stachewicz, I. Peker, W. Tu, and A. H. Barber, “Stress delocalization in crack tolerant electrospun nanofiber networks,” ACS Appl. Mater. Interfaces 3(6), 19911996 (2011).
7.D. Papkov, Y. Zou, M. N. Andalib, A. Goponenko, S. Z. D. Cheng, and Y. A. Dzenis, “Simultaneously strong and tough ultrafine continuous nanofibers,” ACS Nano. 7(4), 33243331 (2013).
8.C. T. Koh, D. G. T. Strange, K. Tonsomboon, and M. L. Oyen, “Failure mechanisms in fibrous scaffolds,” Acta Biomater. 9(7), 73267334 (2013).
9.Z. Huang, Y. Zhang, M. Kotaki, and S. Ramakrishna, “A review on polymer nanofibers by electrospinning and their applications in nanocomposites,” Compos. Sci. Technol. 63, 22232253 (2003).
10.A. Cipitria, A. Skelton, T. R. Dargaville, P. D. Dalton, and D. W. Hutmacher, “Design, fabrication and characterization of PCL electrospun scaffolds,” J. Mater. Chem. 21(26), 9419 (2011).
11.K. Tonsomboon and M. L. Oyen, “Composite electrospun gelatin fiber-alginate gel scaffolds for mechanically robust tissue engineered cornea,” J. Mech. Behav. Biomed. Mater. 21, 185194 (2013).
12.C. Storm, J. J. Pastore, F. C. MacKintosh, T. C. Lubensky, and P. A. Janmey, “Nonlinear elasticity in biological gels,” Nature 435, 191194 (2005).
13.P. R. Onck, T. Koeman, T. Dillen, and E. Giessen, “Alternative explanation of stiffening in cross-linked semiflexible networks,” Phys. Rev. Lett. 95, 178102 (2005).
14.C. T. Koh and M. L. Oyen, “Branching toughens fibrous networks,” J. Mech. Behav. Biomed. Mater. 12, 7482 (2012).
15.C. T. Koh and M. L. Oyen, “Fracture toughness of fibrous membranes,” Technische Mechanik 32(2–5), 333341 (2012).
16.M. F. Kanninen and C. H. Popelar, Advanced Fracture Mechanics (Oxford University Press, 1985), p. 145.
17.Orthopaedic Basic Science, edited by S. R. Simon (American Academy of Orthopaedic Surgeons, 1994).
18.P. Fratzl and R. Weinkamer, “Nature’s hierarchical materials,” Prog. Mater. Sci. 52(8), 12631334 (2007).
19.J. Kastelic, A. Galeski, and E. Baer, “The multicomposite structure of tendon,” Connect. Tissue Res. 6, 1123 (1978).

Data & Media loading...


Article metrics loading...



Electrospun scaffolds mimic the microstructure of structural collagenous tissues and have been widely used in tissue engineering applications. Both brittle cracking and ductile failure have been observed in scaffolds with similarly random fibrous morphology. Finite element analysis can be used to qualitatively examine the mechanics of these differing failure mechanisms. The finite element modeling demonstrates that the noncontinuum deformation of the network structure results in fiber bundle formation and material toughening. Such toughening is accommodated by varying fiber properties, including allowing large failure strains and progressive damage of the fibers.


Full text loading...


Access Key

  • FFree Content
  • OAOpen Access Content
  • SSubscribed Content
  • TFree Trial Content
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd