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Focusing-enhanced mixing in microfluidic channels
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Figures

Image of FIG. 1.

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FIG. 1.

Schematic diagram of a typical focusing-based microfluidic device.

Image of FIG. 2.

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FIG. 2.

Focusing effect as a function of flow rate ratio of sheath flow to the main flow at different joint angles. The dimension for the main flow channel was .

Image of FIG. 3.

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FIG. 3.

Mixing of phenolphthalein ethanol solution and NaOH ethanol solution. The dimension for the main flow channel was . The two fluids were as follows: (a) Unfocused (no sheath flow introduced) at external sheath flow joint; (b) unfocused (no sheath flow introduced) at a distance of 5 mm downstream from the sheath flow joint; (c) focused at the sheath flow joint; (d) focused 5 mm down stream from the sheath flow joint. Sheath fluid was colored with blue ink for better contrasts in (a) and (b).

Image of FIG. 4.

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FIG. 4.

Light intensity analysis across the channel using focusing-based mixing as shown in Figs. 3(c) and 3(d). The flow rate ratio of sheath flow to the main flow was at 4:1.

Image of FIG. 5.

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FIG. 5.

Percentage of mixing in comparison with the theoretical estimation from Eq. (2). The dimension for the main flow channel was . Flow rates of the phenolphthalein and NaOH solutions were at and the flow rate ratio of sheath flow to the main flow was at 4:1.

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/content/aip/journal/bmf/2/1/10.1063/1.2894313
2008-03-03
2014-04-21

Abstract

A focusing-based microfluidic mixer was studied. The micromixer utilizes the focusing process required for cytometry to reduce the diffusion distance of molecules to be mixed in order to facilitate the passive diffusion-controlled mixing process. It was found that both the high flow rate ratio of the sheath flow to the flows to be mixed and the low flow rate of the mixing fluids resulted in the short mixing length required within the microfluidic channel. It was shown that a complete mixing was achieved within a distance of 4 mm in the micromixer for the focused mixing fluids at a flow rate of and a flow rate ratio of the sheath flow to the flows to be mixed at 4:1. The mixer described here is simple and can be easily fabricated and controlled.

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Scitation: Focusing-enhanced mixing in microfluidic channels
http://aip.metastore.ingenta.com/content/aip/journal/bmf/2/1/10.1063/1.2894313
10.1063/1.2894313
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