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Rapid production of protein-loaded biodegradable microparticles using surface acoustic waves
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We present a straightforward and rapid surface acoustic wave(SAW) atomization-based technique for encapsulating proteins into order particles composed of a biodegradablepolymeric excipient, using bovine serum albumin (BSA) as an exemplar. Scans obtained from confocal microscopy provide qualitative proof of encapsulation and show the fluorescent conjugated protein to be distributed in a relatively uniform manner within the polymer shell. An ELISA assay of the collected particles demonstrates that the BSA survives the atomization, particle formation, and collection process with a yield of approximately 55%. The SAW atomization universally gave particles with a textured morphology, and increasing the frequency and polymer concentration generally gave smaller particles (to average) with reduced porosity.
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