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Rapid magnetic heating treatment by highly charged maghemite nanoparticles on Wistar rats exocranial glioma tumors at microliter volume
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View: Figures


Image of FIG. 1.
FIG. 1.

weighted magnetic resonance image of rat head. The glioma tumor area marked with yellow is pointed with a red arrow.

Image of FIG. 2.
FIG. 2.

HRTEM micrographs. (a) Dextran coated crystalline particles (S3) of 10–12 nm in diameter (optimally charged). (b) A single crystalline dextran coated nanoparticle (S3) oriented along the [011] zone axis. (c) A part of bulk maghemite crystals viewed along the direction along with the corresponding selected area electron diffraction pattern. (d) Two uncoated (S1) nanoparticles in twin orientation, where arrows signify the twin boundary. Both are oriented along their corresponding zone axes. The experimental values of the angles between {111}/{200} (55°) and {111}/{220} (35°) crystal planes are shown as well.

Image of FIG. 3.
FIG. 3.

Magnetic heating effect on aqueous dispersions of dextran coated maghemite nanoparticles. (a) The influence of the zeta potential on of ferrofluid S1 (green line), S2 (blue line), and S3 (black line). (b) The influence of the volume on (black line), (blue line), and (red line) of ferrofluid S3. Solid black lines refer to fitting of the experimental data (see text for details). The green line is the curve for water that was used as control sample. In the inset, the coil of the magnetic heating apparatus with the sample and the optical fiber used for the temperature monitoring are shown after removing the heat insulating cover.

Image of FIG. 4.
FIG. 4.

For in vivo magnetic heating of small rat glioma tumors of the S3 ferrofluid was infused into rat glioma tumors with size of 5–10 mm and subsequently subjected to magnetic hyperthermia treatment for 20 min. Panels (a) and (c) (low and high magnifications, respectively) represent sections of control tumor tissue treated without nanoparticles. Panels (b) and (d) (low and high magnifications, respectively) show extensive damage of the tumor tissue after treatment with ferrofluid. White . The lower inset in panel (b) shows the experimental setup for in vivo magnetic heating. The upper inset is an infrared image, which demonstrates the ability of the ferrofluid to produce strong localized heating at the tumor position.


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Scitation: Rapid magnetic heating treatment by highly charged maghemite nanoparticles on Wistar rats exocranial glioma tumors at microliter volume