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Characterization of microfluidic mixing and reaction in microchannels via analysis of cross-sectional patterns
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10.1063/1.3571495
/content/aip/journal/bmf/5/1/10.1063/1.3571495
http://aip.metastore.ingenta.com/content/aip/journal/bmf/5/1/10.1063/1.3571495
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Device description. (a) Schematic representation of an interface in an overlapping flow. (b) Configuration of the devices, models A and B.

Image of FIG. 2.
FIG. 2.

Schematic diagram of the confocal-fluorescence system.

Image of FIG. 3.
FIG. 3.

Scheme for mixing quantification. (a) 3D reconstructed confocal image, (b) method of mixing quantification for mixing patterns, (c) calibration curve of intensity and fluorophore , and (d) normalized calibration curve.

Image of FIG. 4.
FIG. 4.

Validation of a confocal-fluorescence system. (a) Configuration of T-shaped channel (left) and mixing patterns of experimental (confocal) and simulation results at confluence and outlet (right); intensity distributions at the confluence (b) and the outlet (c).

Image of FIG. 5.
FIG. 5.

Mass exchange of devices: (a) model A and (b) model B.

Image of FIG. 6.
FIG. 6.

Flow advection of devices: (a) model A and (b) model B.

Image of FIG. 7.
FIG. 7.

Mixing quantification of the devices at and . (a) Mixing patterns of the devices at various nodes, (b) relation between the mixing quality index and the mixing distance (node), and (c) dye-liquor blending test in the device, model B.

Image of FIG. 8.
FIG. 8.

FRET reaction of two complementary DNA oligonucleotides in the devices. (a) Fluorescence distribution of two oligonucleotides at the various cross sections of the devices . (b) Ratio of fluorescence intensity .

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/content/aip/journal/bmf/5/1/10.1063/1.3571495
2011-03-24
2014-04-18
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Characterization of microfluidic mixing and reaction in microchannels via analysis of cross-sectional patterns
http://aip.metastore.ingenta.com/content/aip/journal/bmf/5/1/10.1063/1.3571495
10.1063/1.3571495
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