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Formation of multilayered biopolymer microcapsules and microparticles in a multiphase microfluidic flow
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10.1063/1.4722296
/content/aip/journal/bmf/6/2/10.1063/1.4722296
http://aip.metastore.ingenta.com/content/aip/journal/bmf/6/2/10.1063/1.4722296

Figures

Image of FIG. 1.
FIG. 1.

(a) Schematic of the microfluidic flow focusing geometry used for the continuous production of single and multilayer biopolymer microparticles. Insert—corresponding dimensions of flow-focusing section. (b) Schematic showing regions of the microfluidic device: droplet formation, solidification and deposition of a single (coating) layer.

Image of FIG. 2.
FIG. 2.

Evolution of storage modulus as a function of time during the redox-initiated cross-linking reaction of F68DA 15 wt. % aqueous solution (triangles) at 40 rad/s and 10% strain and 20wt. % solution (spheres) at 40 rad/s and 15% strain. The induction time of the reaction varies when decreasing the concentration of accelerator (TEMED) in the original reactive solution from 30 ml/g(DA PF-68) (open symbols) to 15 ml/g(DA PF-68) (filled symbols). The concentration of APS is the same for all initial reactive solutions: 4% (w/w(DA PF-68)). There is no effect of the amount of TEMED on the final modulus.

Image of FIG. 3.
FIG. 3.

Images showing differences in droplet size as a function of flowrates of continuous and dispersed phases. (a) QC =0.5 ml/h, QD= 2 ml/h, (b) QC = 0.5 ml/h, QD = 6 ml/h, (c) QC = 1 ml/h, QD = 8 ml/h.

Image of FIG. 4.
FIG. 4.

(a) SEM image of DA F-127 cross-linked microparticles produced on-chip via a redox-initiated reaction. The particle size is approximately 1 μm. (b) TEM images of the same system. Note the dense core and diffuse shell.

Image of FIG. 5.
FIG. 5.

Absorption spectra for (1) V56 in DI water, (2) a glass slide, (3) a quartz slide.

Image of FIG. 6.
FIG. 6.

(a) Optical microscopy image of a DA PF-127 capsule flowing in the channel post UV initiation, showing the formation of a shell of different density to the centre of the particle. (b) Optical microscopy images of DA PF-127 photo cross-linked particles deposited on a microscope slide after collection from the device. (c) SEM images of DA PF-68 (1) and DA PF-127 (2) cross-linked microcapsules produced on-chip via a photo-initiated reaction. The particle size is approximately 60 and 80 μm, respectively.

Image of FIG. 7.
FIG. 7.

(a) Axisymmetric co-flowing channel configuration for the introduction of a MVP solution into the main channel where DA PF-127 droplets/particles are flowing. The two continuous phases are partially miscible and do not diffuse into each other instantaneously. A DEAP solution in DMC is introduced further downstream. (b) A solution of 2 wt. % PLA-PEO-PLA in DMC is introduced via the first set of co-flowing channels and hexadecane is introduced via the second flow-focusing junction to push down the polymer solution onto the surface of the particles.

Image of FIG. 8.
FIG. 8.

SEM images of (a) DA PF-68 cross-linked microcapsules coated with PLA-PEO-PLA, (b) DA PF-127 cross-linked microcapsules coated with PVP, (c) DA PF-127 cross-linked microparticles coated with a 1st layer of PVP and a 2nd layer of PLA-PEO-PLA.

Image of FIG. 9.
FIG. 9.

Images obtained with an inverted microscope Olympus IX81 using (a) a phase contrast objective and (b) a green fluorescent filter.

Image of FIG. 10.
FIG. 10.

Release data and profiles for vitronectin (grey line), HRP (dotted line) and vitamin B12 (black line), from cross-linked DA PF-127 macro (bulk)-gels. The amount of vitronectin released after 4, 5 and 6 days from DA PF-127 cross-linked microparticles prepared on-chip is reported (triangles) for comparison.

Image of FIG. 11.
FIG. 11.

Release profiles for Vitamin B12 encapsulated in cross-linked DA PF-68 macrogels (open symbols, dotted line) and in the case of cross-linked DA PF-68 particles produced within the microfluidic device (solid symbols, full line).

Tables

Generic image for table
Table I.

Residence times of the droplets/particles in the channel, as a function of the flow rate of the continuous phase (QC), in Zone 1 and in Zone 2 (see Figure 5 for partition).

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/content/aip/journal/bmf/6/2/10.1063/1.4722296
2012-05-24
2014-04-24
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Formation of multilayered biopolymer microcapsules and microparticles in a multiphase microfluidic flow
http://aip.metastore.ingenta.com/content/aip/journal/bmf/6/2/10.1063/1.4722296
10.1063/1.4722296
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