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Droplet based microfluidic fabrication of designer microparticles for encapsulation applications
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Image of FIG. 1.
FIG. 1.

(a) Schematic of experimental setup; (b) microfluidic generation of monodisperse oil-in-water single emulsion droplets; (c) typical monodisperse droplet templates produced using capillary microfluidic devices (enhanced online). [URL: http://dx.doi.org/10.1063/1.4738586.1]10.1063/1.4738586.1

Image of FIG. 2.
FIG. 2.

Schematic showing the effect of solvent evaporation on the particle size and size distribution with bulk emulsification techniques (top) and droplet microfluidics (bottom).

Image of FIG. 3.
FIG. 3.

(a) Schematic of two possible routes by which the polydispersity of microparticles increases; (b) optical microscope image and (c) SEM image of monodisperse microspheres formed by solvent evaporation from emulsion droplet templates without stirring; (d) optical microscope images of suspensions of monodisperse solidified microspheres stirred at 100 rpm.

Image of FIG. 4.
FIG. 4.

Optical microscope images of microparticle suspensions stirred at (a) 800 rpm for 2.5 h, (b) 15 h, (c) 46 h, (d) a plot of the average diameter of PLGA microparticles (with the error bars denoting a standard deviation for each data point) as a function of stirring time using a magnetic stirrer.

Image of FIG. 5.
FIG. 5.

(a) A plot of rifampicin release rate as a function of time; (b) schematic illustration of a proposed release mechanism of drugs from PLGA microparticles as drug carriers.

Image of FIG. 6.
FIG. 6.

Release rate of rifampicin from microparticles fabricated at different stirring speeds for the same period of time.

Image of FIG. 7.
FIG. 7.

(a) A plot of drug encapsulation efficiency as a function of stirring time; (b) initial drug release rate of rifampicin from microparticles fabricated using the same stirring speed for different periods of time; (c) cumulative percentage of rifampicin released from microparticles fabricated by stirring for different periods of time.



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Scitation: Droplet based microfluidic fabrication of designer microparticles for encapsulation applications