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Entropic depletion of DNA in triangular nanochannels
6. E. T. Lam, A. Hastie, C. Lin, D. Ehrlich, S. K. Das, M. D. Austin, P. Deshpande, H. Cao, N. Nagarajan, M. Xiao, and P. Y. Kwok, Nat. Biotechnol. 30, 771 (2012).
8. K. D. Dorfman, S. B. King, D. W. Olson, J. D. P. Thomas, and D. R. Tree, “ Beyond gel electrophoresis: Microfluidic separations, fluorescence burst analysis, and DNA stretching,” Chem. Rev. (published online).
12. P. Fanzio, C. Manneschi, E. Angeli, V. Mussi, G. Firpo, L. Cesaracciu, L. Repetto, and U. Valbusa, Sci. Rep. 2, 791 10.1038/srep00791 (2012).
24. W. Reisner, K. J. Morton, R. Riehn, Y. M. Wang, Z. Yu, M. Rosen, J. C. Sturm, S. Y. Chou, E. Frey, and R. H. Austin, Phys. Rev. Lett. 94, 196101 (2005).
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Using Monte Carlo simulations of a touching-bead model of double-stranded DNA, we show that DNA extension is enhanced in isosceles triangular nanochannels (relative to a circular nanochannel of the same effective size) due to entropic depletion in the channel corners. The extent of the enhanced extension depends non-monotonically on both the accessible area of the nanochannel and the apex angle of the triangle. We also develop a metric to quantify the extent of entropic depletion, thereby collapsing the extension data for circular, square, and various triangular nanochannels onto a single master curve for channel sizes in the transition between the Odijk and de Gennes regimes.
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