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Development of vertical SU-8 microtubes integrated with dissolvable tips for transdermal drug delivery
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10.1063/1.4798471
/content/aip/journal/bmf/7/2/10.1063/1.4798471
http://aip.metastore.ingenta.com/content/aip/journal/bmf/7/2/10.1063/1.4798471

Figures

Image of FIG. 1.
FIG. 1.

Schematic illustration of the SU-8 microneedles. (a) Top view of the device structure. (b) A 5×5 SU-8 microneedles array. (c) Cross section of the device structure. (d) Single microneedle structure.

Image of FIG. 2.
FIG. 2.

Fabrication process for SU-8 microtubes.

Image of FIG. 3.
FIG. 3.

(a) Schematic illustration of the homemade stage to ensure flat SU-8 membrane surface. (b) SU-8 membrane bends after development. (c) After bonded with PDMS and clamped in the stage, the membrane becomes flat.

Image of FIG. 4.
FIG. 4.

Fabrication process for maltose tips. (a) Expelling water at 140 °C. (b) Immersing microtubes into the maltose at 140 °C. (c) Drawing the tips at end of the microtubes when the temperature increases up to 160 °C. (d) Increasing drawing speed to form sharp tips.

Image of FIG. 5.
FIG. 5.

(a) Optical image for the finished SU-8 microneedles. (b) Detailed illustration image for the microneedles array.

Image of FIG. 6.
FIG. 6.

(a) Testing setup for the microneedle mechanical testing. (b) A typical microneedle stiffness testing result.

Image of FIG. 7.
FIG. 7.

Penetration testing results on the porcine cadaver skin.

Image of FIG. 8.
FIG. 8.

Maltose tips dissolving process. (a) The original sharp maltose tip. (b) Maltose tip after inserted into skin for 3 min. (c) Maltose tip after inserted into skin for 6 min. (d) Maltose tip after inserted into skin for 9 min.

Image of FIG. 9.
FIG. 9.

Images of confocal microscopy of the site where one microneedle inserted shows that the fluorescent solution is delivered into the tissue underneath the skin surface. Optical section depths are (a) 30 μm, (b) 60 μm, (c) 90 μm, (d) 120 μm, (e) 150 μm, and (f) 180 μm below the skin surface.

Tables

Generic image for table
Table I.

Ratio of individual maltose tips to clustered maltose tips among a 5 × 5 microneedles array.

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/content/aip/journal/bmf/7/2/10.1063/1.4798471
2013-03-26
2014-04-17
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Development of vertical SU-8 microtubes integrated with dissolvable tips for transdermal drug delivery
http://aip.metastore.ingenta.com/content/aip/journal/bmf/7/2/10.1063/1.4798471
10.1063/1.4798471
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