No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
Hydrodynamic mechanisms of cell and particle trapping in microfluidics
1. M. Danova, M. Torchio, and G. Mazzini, “Isolation of rare circulating tumor cells in cancer patients: Technical aspects and clinical implications,” Expert Rev. Mol. Diagn. 11, 473–485 (2011).
2. D. C. Colter, I. Sekiya, and D. J. Prockop, “Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells,” Proc. Natl. Acad. Sci. 98, 7841–7845 (2001).
3. K. Jo, Y.-L. Chen, J. J. de Pablo, and D. C. Schwartz, “Elongation and migration of single DNA molecules in microchannels using oscillatory shear flows,” Lab Chip 9, 2348–2355 (2009).
5. A. van de Stolpe, K. Pantel, S. Sleijfer, L. W. Terstappen, and J. M. J. den Toonder, “Circulating tumor cell isolation and diagnostics: Toward routine clinical use,” Cancer Res. 71, 5955–5960 (2011).
6. X. Cheng, D. Irimia, M. Dixon, K. Sekine, U. Demirci, L. Zamir, R. G. Tompkins, W. Rodriguez, and M. Toner, “A microfluidic device for practical label-free CD4+ T cell counting of HIV-infected subjects,” Lab Chip 7, 170–178 (2007).
8. D. Gänshirt, F. W. M. Smeets, A. Dohr, C. Walde, I. Steen, C. Lapucci, C. Falcinelli, R. Sant, M. Velasco, and H. S. P. Garritsen, “Enrichment of fetal nucleated red blood cells from the maternal circulation for prenatal diagnosis: Experiences with triple density gradient and MACS based on more than 600 cases,” Fetal Diagn. Ther. 13, 276–286 (1998).
9. G. Vona, A. Sabile, M. Louha, V. Sitruk, S. Romana, K. Schütze, F. Capron, D. Franco, M. Pazzagli, M. Vekemans et al., “Isolation by size of epithelial tumor cells: A new method for the immunomorphological and molecular characterization of circulating tumor cells,” Am. J. Pathol. 156, 57–63 (2000).
10. C. Alix-Panabières, J. Vendrell, O. Pellé, X. Rebillard, S. Riethdorf, V. Müller, M. Fabbro, and K. Pantel, “Detection and characterization of putative metastatic precursor cells in cancer patients,” Clin. Chem. 53, 537–539 (2007).
11. H. M. Shapiro, Practical Flow Cytometry, 4th ed. (Wiley-Liss, New York, 2003).
14. A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature (London) 457, 71–75 (2009).
16. H. Lee, A. M. Purdon, and R. M. Westervelt, “Manipulation of biological cells using a microelectromagnet matrix,” Appl. Phys. Lett. 85, 1063–1065 (2004).
17. M. Evander, L. Johansson, T. Lilliehorn, J. Piskur, M. Lindvall, S. Johansson, M. Almqvist, T. Laurell, and J. Nilsson, “Noninvasive acoustic cell trapping in a microfluidic perfusion system for online bioassays,” Anal. Chem. 79, 2984–2991 (2007).
18. R. Dylla-Spears, J. E. Townsend, L. Jen-Jacobson, L. L. Sohn, and S. J. Muller, “Single-molecule sequence detection via microfluidic planar extensional flow at a stagnation point,” Lab Chip 10, 1543–1549 (2010).
19. R. Pethig, “Review article—dielectrophoresis: Status of the theory, technology, and applications,” Biomicrofluidics 4, 022811 (2010).
20. S. Patel, D. Showers, P. Vedantam, T. R. Tzeng, S. Qian, and X. Xuan, “Microfluidic separation of live and dead yeast cells using reservoir-based dielectrophoresis,” Biomicrofluidics 6, 034102 (2012).
21. Z. Gagnon, J. Mazur, and H. C. Chang, “Glutaraldehyde enhanced dielectrophoretic yeast cell separation,” Biomicrofluidics 3, 044108 (2009).
22. M. Muratore, V. Srsen, M. Waterfall, A. Downes, and R. Pethig, “Biomarker-free dielectrophoretic sorting of differentiating myoblast multipotent progenitor cells and their membrane analysis by Raman spectroscopy,” Biomicrofluidics 6, 034113 (2012).
23. S. N. Murthy, “Magnetophoresis: An approach to enhance transdermal drug diffusion,” Die Pharmazie 54, 377 (1999).
24. J. S. Heyman, “Acoustophoresis separation method,” U.S. patent 5,192,450 (1993).
26. M. Yamada, M. Nakashima, and M. Seki, “Pinched flow fractionation: Continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel,” Anal. Chem. 76, 5465–5471 (2004).
27. T. A. Crowley and V. Pizziconi, “Isolation of plasma from whole blood using planar microfilters for lab-on-a-chip applications,” Lab Chip 5, 922–929 (2005).
28. S. Yang, A. Ündar, and J. D. Zahn, “A microfluidic device for continuous, real time blood plasma separation,” Lab Chip 6, 871–880 (2006).
29. S. Choi, S. Song, C. Choi, and J. K. Park, “Continuous blood cell separation by hydrophoretic filtration,” Lab Chip 7, 1532–1538 (2007).
30. J. A. Davis, D. W. Inglis, K. J. Morton, D. A. Lawrence, L. R. Huang, S. Y. Chou, J. C. Sturm, and R. H. Austin, “Deterministic hydrodynamics: Taking blood apart,” Proc. Natl. Acad. Sci. 103, 14779–14784 (2006).
32. A. Lenshof and T. Laurell, “Continuous separation of cells and particles in microfluidic systems,” Chem. Soc. Rev. 39, 1203–1217 (2010).
34. D. R. Gossett, W. M. Weaver, A. J. Mach, S. C. Hur, H. T. K. Tse, W. Lee, H. Amini, and D. Di Carlo, “Label-free cell separation and sorting in microfluidic systems,” Anal. Bioanal. Chem. 397, 3249–3267 (2010).
35. J. Chen, J. Li, and Y. Sun, “Microfluidic approaches for cancer cell detection, characterization, and separation,” Lab Chip 12, 1753–1767 (2012).
36. J. Autebert, B. Coudert, F. C. Bidard, J. Y. Pierga, S. Descroix, L. Malaquin, and J. L. Viovy, “Microfluidic: An innovative tool for efficient cell sorting,” Methods 57, 297–307 (2012).
41. L. G. Leal, Advanced Transport Phenomena: Fluid Mechanics and Convective Transport Processes (Cambridge University Press, Cambridge, 2007).
43. G. Segre and A. Silberberg, “Behaviour of macroscopic rigid spheres in Poiseuille flow. Part 1. Determination of local concentration by statistical analysis of particle passages through crossed light beams,” J. Fluid Mech. 14, 115–135 (1962).
44. G. Segre and A. Silberberg, “Behaviour of macroscopic rigid spheres in Poiseuille flow. Part 2. Experimental results and interpretation,” J. Fluid Mech. 14, 136–157 (1962).
54. Y. S. Choi, K. W. Seo, and S. J. Lee, “Lateral and cross-lateral focusing of spherical particles in a square microchannel,” Lab Chip 11, 460–465 (2011).
55. J. Feng, H. H. Hu, and D. D. Joseph, “Direct simulation of initial value problems for the motion of solid bodies in a Newtonian fluid. Part 2. Couette and Poiseuille flows,” J. Fluid Mech. 277, 271–301 (1994).
57. B. Chun and A. J. C. Ladd, “Inertial migration of neutrally buoyant particles in a square duct: An investigation of multiple equilibrium positions,” Phys. Fluids 18, 031704 (2006).
59. D. R. Gossett, H. T. K. Tse, J. S. Dudani, K. Goda, T. A. Woods, S. W. Graves, and D. Di Carlo, “Inertial manipulation and transfer of microparticles across laminar fluid streams,” Small 8, 2757–2764 (2012).
60. A. A. S. Bhagat, H. W. Hou, L. D. Li, C. T. Lim, and J. Han, “Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation,” Lab Chip 11, 1870–1878 (2011).
61. J. Oakey, R. W. Applegate, Jr., E. Arellano, D. D. Carlo, S. W. Graves, and M. Toner, “Particle focusing in staged inertial microfluidic devices for flow cytometry,” Anal. Chem. 82, 3862–3867 (2010).
62. X. Mao, J. R. Waldeisen, and T. J. Huang, “‘Microfluidic drifting’–Implementing three-dimensional hydrodynamic focusing with a single-layer planar microfluidic device,” Lab Chip 7, 1260–1262 (2007).
63. D. Di Carlo, D. Irimia, R. G. Tompkins, and M. Toner, “Continuous inertial focusing, ordering, and separation of particles in microchannels,” Proc. Natl. Acad. Sci. 104, 18892–18897 (2007).
64. S. C. Hur, H. T. K. Tse, and D. Di Carlo, “Sheathless inertial cell ordering for extreme throughput flow cytometry,” Lab Chip 10, 274–280 (2010).
65. Z. Wu, B. Willing, J. Bjerketorp, J. K. Jansson, and K. Hjort, “Soft inertial microfluidics for high throughput separation of bacteria from human blood cells,” Lab Chip 9, 1193–1199 (2009).
66. S. C. Hur, N. K. Henderson-MacLennan, E. R. B. McCabe, and D. Di Carlo, “Deformability-based cell classification and enrichment using inertial microfluidics,” Lab Chip 11, 912–920 (2011).
67. S. S. Kuntaegowdanahalli, A. A. S. Bhagat, G. Kumar, and I. Papautsky, “Inertial microfluidics for continuous particle separation in spiral microchannels,” Lab Chip 9, 2973–2980 (2009).
68. W. Lee, H. Amini, H. A. Stone, and D. Di Carlo, “Dynamic self-assembly and control of microfluidic particle crystals,” Proc. Natl. Acad. Sci. 107, 22413–22418 (2010).
69. A. J. Mach and D. Di Carlo, “Continuous scalable blood filtration device using inertial microfluidics,” Biotechnol. Bioeng. 107, 302–311 (2010).
70. D. Di Carlo, F. Jon, D. Irimia, R. G. Tompkins, and M. Toner, “Equilibrium separation and filtration of particles using differential inertial focusing,” Anal. Chem. 80, 2204–2211 (2008).
71. A. A. S. Bhagat, S. S. Kuntaegowdanahalli, and I. Papautsky, “Inertial microfluidics for continuous particle filtration and extraction,” Microfluid. Nanofluid. 7, 217–226 (2009).
72. S. C. Hur, A. J. Mach, and D. Di Carlo, “High-throughput size-based rare cell enrichment using microscale vortices,” Biomicrofluidics 5, 022206 (2011).
74. J. Takagi, M. Yamada, M. Yasuda, and M. Seki, “Continuous particle separation in a microchannel having asymmetrically arranged multiple branches,” Lab Chip 5, 778–784 (2005).
75. M. Yamada and M. Seki, “Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics,” Lab Chip 5, 1233–1239 (2005).
76. L. R. Huang, E. C. Cox, R. H. Austin, and J. C. Sturm, “Continuous particle separation through deterministic lateral displacement,” Science 304, 987–990 (2004).
77. D. W. Inglis, J. A. Davis, R. H. Austin, and J. C. Sturm, “Critical particle size for fractionation by deterministic lateral displacement,” Lab Chip 6, 655–658 (2006).
78. B. R. Long, M. Heller, J. P. Beech, H. Linke, H. Bruus, and J. O. Tegenfeldt, “Multidirectional sorting modes in deterministic lateral displacement devices,” Phys. Rev. E 78, 046304 (2008).
79. S. Choi and J. K. Park, “Continuous hydrophoretic separation and sizing of microparticles using slanted obstacles in a microchannel,” Lab Chip 7, 890–897 (2007).
80. S. Choi, S. Song, C. Choi, and J. K. Park, “Microfluidic self-sorting of mammalian cells to achieve cell cycle synchrony by hydrophoresis,” Anal. Chem. 81, 1964–1968 (2009).
81. J. S. Park, S. H. Song, and H. I. Jung, “Continuous focusing of microparticles using inertial lift force and vorticity via multi-orifice microfluidic channels,” Lab Chip 9, 939–948 (2009).
82. J. S. Park and H. I. Jung, “Multiorifice flow fractionation: Continuous size-based separation of microspheres using a series of contraction/expansion microchannels,” Anal. Chem. 81, 8280–8288 (2009).
83. A. Karnis and S. G. Mason, “Particle motions in sheared suspensions. XIX. Viscoelastic media,” Trans. Soc. Rheol. 10, 571–592 (1966).
84. F. Gauthier, H. L. Goldsmith, and S. G. Mason, “Particle motions in non-Newtonian media. II. Poiseuille flow,” Trans. Soc. Rheol. 15, 297–330 (1971).
86. M. A. Tehrani, “An experimental study of particle migration in pipe flow of viscoelastic fluids,” J. Rheol. 40, 1057–1077 (1996).
88. P. Y. Huang, J. Feng, H. H. Hu, and D. D. Joseph, “Direct simulation of the motion of solid particles in Couette and Poiseuille flows of viscoelastic fluids,” J. Fluid Mech. 343, 73–94 (1997).
90. A. M. Ardekani, R. H. Rangel, and D. D. Joseph, “Two spheres in a free stream of a second-order fluid,” Phys. Fluids 20, 063101 (2008).
92. P. Y. Huang and D. D. Joseph, “Effects of shear thinning on migration of neutrally buoyant particles in pressure driven flow of Newtonian and viscoelastic fluids,” J. Non-Newtonian Fluid Mech. 90, 159–185 (2000).
93. R. B. Bird, R. C. Armstrong, and O. Hassager, Dynamics of Polymeric Liquids: Fluid Mechanics (John Wiley and Sons, Inc., New York, NY, 1987), Vol. 1.
95. S. Yang, S. S. Lee, S. W. Ahn, K. Kang, W. Shim, G. Lee, K. Hyun, and J. M. Kim, “Deformability-selective particle entrainment and separation in a rectangular microchannel using medium viscoelasticity,” Soft Matter 8, 5011–5019 (2012).
96. G. D'Avino, P. L. Maffettone, F. Greco, and M. A. Hulsen, “Viscoelasticity-induced migration of a rigid sphere in confined shear flow,” J. Non-Newtonian Fluid Mech. 165, 466–474 (2010).
97. G. D'Avino, G. Romeo, M. M. Villone, F. Greco, P. A. Netti, and P. L. Maffettone, “Single line particle focusing induced by viscoelasticity of the suspending liquid: Theory, experiments and simulations to design a micropipe flow-focuser,” Lab Chip 12, 1638–1645 (2012).
98. J. Y. Kim, S. W. Ahn, S. S. Lee, and J. M. Kim, “Lateral migration and focusing of colloidal particles and DNA molecules under viscoelastic flow,” Lab Chip 12, 2807–2814 (2012).
99. S. Yang, J. Y. Kim, S. J. Lee, S. S. Lee, and J. M. Kim, “Sheathless elasto-inertial particle focusing and continuous separation in a straight rectangular microchannel,” Lab Chip 11, 266–273 (2011).
100. J. Nam, H. Lim, D. Kim, H. Jung, and S. Shin, “Continuous separation of microparticles in a microfluidic channel via the elasto-inertial effect of non-Newtonian fluid,” Lab Chip 12, 1347–1354 (2012).
102. F. C. Mokken, M. Kedaria, C. P. Henny, M. R. Hardeman, and A. W. Gelb, “The clinical importance of erythrocyte deformability, a hemorrheological parameter,” Ann. Hematol. 64, 113–122 (1992).
105. S. K. Ballas, “Sickle cell anemia with few painful crises is characterized by decreased red cell deformability and increased number of dense cells,” Am. J. Hematol. 36, 122–130 (2006).
107. F. Takemura, S. Takagi, J. Magnaudet, and Y. Matsumoto, “Drag and lift forces on a bubble rising near a vertical wall in a viscous liquid,” J. Fluid Mech. 461, 277–300 (2002).
108. F. Takemura and J. Magnaudet, “The transverse force on clean and contaminated bubbles rising near a vertical wall at moderate Reynolds number,” J. Fluid Mech. 495, 235–253 (2003).
111. S. Mortazavi and G. Tryggvason, “A numerical study of the motion of drops in Poiseuille flow. Part 1. Lateral migration of one drop,” J. Fluid Mech. 411, 325–350 (2000).
114. W. S. J. Uijttewaal, E. J. Nijhof, and R. M. Heethaar, “Droplet migration, deformation, and orientation in the presence of a plane wall: A numerical study compared with analytical theories,” Phys. Fluids A: Fluid Dyn. 5, 819–825 (1993).
115. G. Coupier, B. Kaoui, T. Podgorski, and C. Misbah, “Noninertial lateral migration of vesicles in bounded Poiseuille flow,” Phys. Fluids 20, 111702 (2008).
118. U. Seifert, K. Berndl, and R. Lipowsky, “Shape transformations of vesicles: Phase diagram for spontaneous-curvature and bilayer-coupling models,” Phys. Rev. A 44, 1182 (1991).
122. B. Alberts, Molecular Biology of the Cell, 4th ed. (Garland Science, New York, 2002).
123. R. Dimova, K. A. Riske, S. Aranda, N. Bezlyepkina, R. L. Knorr, and R. Lipowsky, “Giant vesicles in electric fields,” Soft Matter 3, 817–827 (2007).
127. B. Kaoui, G. H. Ristow, I. Cantat, C. Misbah, and W. Zimmermann, “Lateral migration of a two-dimensional vesicle in unbounded Poiseuille flow,” Phys. Rev. E 77, 021903 (2008).
128. T. M. Geislinger, B. Eggart, S. Braunmuller, L. Schmid, and T. Franke, “Separation of blood cells using hydrodynamic lift,” Appl. Phys. Lett. 100, 183701 (2012).
131. S. Ookawara, R. Higashi, D. Street, and K. Ogawa, “Feasibility study on concentration of slurry and classification of contained particles by microchannel,” Chem. Eng. J. 101, 171–178 (2004).
134. X. Mao, S. C. S. Lin, C. Dong, and T. J. Huang, “Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing,” Lab Chip 9, 1583–1589 (2009).
135. A. A. S. Bhagat, S. S. Kuntaegowdanahalli, and I. Papautsky, “Continuous particle separation in spiral microchannels using Dean flows and differential migration,” Lab Chip 8, 1906–1914 (2008).
136. A. A. S. Bhagat, S. S. Kuntaegowdanahalli, N. Kaval, C. J. Seliskar, and I. Papautsky, “Inertial microfluidics for sheath-less high-throughput flow cytometry,” Biomed. Microdevices 12, 187–195 (2010).
138. J. Zhu and X. Xuan, “Curvature-induced dielectrophoresis for continuous separation of particles by charge in spiral microchannels,” Biomicrofluidics 5, 024111 (2011).
139. E. W. M. Kemna, R. M. Schoeman, F. Wolbers, I. Vermes, D. A. Weitz, and A. van den Berg, “High-yield cell ordering and deterministic cell-in-droplet encapsulation using Dean flow in a curved microchannel,” Lab Chip 12, 2881–2887 (2012).
140. C. Church, J. Zhu, G. Wang, T. R. J. Tzeng, and X. Xuan, “Electrokinetic focusing and filtration of cells in a serpentine microchannel,” Biomicrofluidics 3, 044109 (2009).
141. W. C. Lee, A. A. S. Bhagat, S. Huang, K. J. Van Vliet, J. Han, and C. T. Lim, “High-throughput cell cycle synchronization using inertial forces in spiral microchannels,” Lab Chip 11, 1359–1367 (2011).
142. C. M. Lin, Y. S. Lai, H. P. Liu, C. Y. Chen, and A. M. Wo, “Trapping of bioparticles via microvortices in a microfluidic device for bioassay applications,” Anal. Chem. 80, 8937–8945 (2008).
143. H. M. Hertz, “Standing-wave acoustic trap for nonintrusive positioning of microparticles,” J. Appl. Phys. 78, 4845–4849 (1995).
145. A. Gonzalez, A. Ramos, N. G. Green, A. Castellanos, and H. Morgan, “Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. II. A linear double-layer analysis,” Phys. Rev. E 61, 4019–4028 (2000).
146. L. Y. Yeo, D. Hou, S. Maheshswari, and H. Chang, “Electrohydrodynamic surface microvortices for mixing and particle trapping,” Appl. Phys. Lett. 88, 233512 (2006).
147. D. Hou, S. Maheshwari, and H. Chang, “Rapid bioparticle concentration and detection by combining a discharge driven vortex with surface enhanced Raman scattering,” Biomicrofluidics 1, 014106 (2007).
149. D. Ahmed, X. Mao, J. Shi, B. K. Juluri, and T. J. Huang, “A millisecond micromixer via single-bubble-based acoustic streaming,” Lab Chip 9, 2738–2741 (2009).
150. D. Ahmed, X. Mao, B. K. Juluri, and T. J. Huang, “A fast microfluidic mixer based on acoustically driven sidewall-trapped microbubbles,” Microfluid. Nanofluid. 7, 727–731 (2009).
151. R. H. Liu, J. Yang, M. Z. Pindera, M. Athavale, and P. Grodzinski, “Bubble-induced acoustic micromixing,” Lab Chip 2, 151–157 (2002).
153. K. Ryu, S. K. Chung, and S. K. Cho, “Micropumping by an acoustically excited oscillating bubble for automated implantable microfluidic devices,” J. Assoc. Lab Autom. 15, 163–171 (2010).
154. Y. Xie, D. Ahmed, M. I. Lapsley, S. C. S. Lin, A. A. Nawaz, L. Wang, and T. J. Huang, “Single-shot characterization of enzymatic reaction constants Km and kcat by an acoustic-driven, bubble-based fast micromixer,” Anal. Chem. 84(17), 7495–7501 (2012).
155. P. Marmottant and S. Hilgenfeldt, “Controlled vesicle deformation and lysis by single oscillating bubbles,” Nature (London) 423, 153–156 (2003).
156. C. Wang, S. V. Jalikop, and S. Hilgenfeldt, “Size-sensitive sorting of microparticles through control of flow geometry,” Appl. Phys. Lett. 99, 034101 (2011).
157. C. Wang, S. V. Jalikop, and S. Hilgenfeldt, “Efficient manipulation of microparticles in bubble streaming flows,” Biomicrofluidics 6, 012801 (2012).
158. A. Hashmi, G. Yu, M. Reilly-Collette, G. Heiman, and J. Xu, “Oscillating bubbles: A versatile tool for lab on a chip applications,” Lab Chip 12, 4216–4227 (2012).
160. J. S. Raut, S. D. Stoyanov, C. Duggal, E. G. Pelan, L. N. Arnaudov, and V. M. Naik, “Hydrodynamic cavitation: A bottom-up approach to liquid aeration,” Soft Matter 8, 4562–4566 (2012).
162. W. L. Nyborg, Acoustic Streaming (Academic Press, New York, 1965), Vol. 2.
165. C. Pozrikidis, Boundary Integral and Singularity Methods for Linearized Viscous Flow (Cambridge University Press, Cambridge, 1992), Vol. 7.
167. K. V. Sharp, S. H. Yazdi, and S. M. Davison, “Localized flow control in microchannels using induced-charge electroosmosis near conductive obstacles,” Microfluid. Nanofluid. 10, 1257–1267 (2011).
168. J. A. Levitan, S. Devasenathipathy, V. Studer, Y. Ben, T. Thorsen, T. M. Squires, and M. Z. Bazant, “Experimental observation of induced-charge electro-osmosis around a metal wire in a microchannel,” Colloids Surf., A 267, 122–132 (2005).
169. S. H. Yazdi and A. M. Ardekani, “Bacterial aggregation and biofilm formation in a vortical flow,” Biomicrofluidics 6, 044114 (2012).
170. B. R. Lutz, J. Chen, and D. T. Schwartz, “Microscopic steady streaming eddies created around short cylinders in a channel: Flow visualization and stokes layer scaling,” Phys. Fluids 17, 023601 (2005).
171. B. R. Lutz, J. Chen, and D. T. Schwartz, “Hydrodynamic tweezers: 1. Noncontact trapping of single cells using steady streaming microeddies,” Anal. Chem. 78, 5429–5435 (2006).
172. V. H. Lieu, T. A. House, and D. T. Schwartz, “Hydrodynamic tweezers: Impact of design geometry on flow and microparticle trapping,” Anal. Chem. 84, 1963–1968 (2012).
173. S. Ahuja, Chiral Separations: Applications and Technology (American Chemical Society, Washington, DC, 1997).
177. W. M. Durham, J. O. Kessler, and R. Stocker, “Disruption of vertical motility by shear triggers formation of thin phytoplankton layers,” Science 323, 1067–1070 (2009).
178. N. Hashemi, J. S. Erickson, J. P. Golden, and F. S. Ligler, “Optofluidic characterization of marine algae using a microflow cytometer,” Biomicrofluidics 5, 032009 (2011).
Article metrics loading...
Focusing and sorting cells and particles utilizing microfluidic phenomena have been flourishing areas of development in recent years. These processes are largely beneficial in biomedical applications and fundamental studies of cell biology as they provide cost-effective and point-of-care miniaturized diagnostic devices and rare cell enrichment techniques. Due to inherent problems of isolation methods based on the biomarkers and antigens, separation approaches exploiting physical characteristics of cells of interest, such as size, deformability, and electric and magnetic properties, have gained currency in many medical assays. Here, we present an overview of the cell/particle sorting techniques by harnessing intrinsic hydrodynamic effects in microchannels. Our emphasis is on the underlying fluid dynamical mechanisms causing cross stream migration of objects in shear and vortical flows. We also highlight the advantages and drawbacks of each method in terms of throughput, separation efficiency, and cell viability. Finally, we discuss the future research areas for extending the scope of hydrodynamic mechanisms and exploring new physical directions for microfluidic applications.
Full text loading...
Most read this month