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Viscoelasticity of blood and viscoelastic blood analogues for use in polydymethylsiloxane in vitro models of the circulatory system
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10.1063/1.4804649
/content/aip/journal/bmf/7/3/10.1063/1.4804649
http://aip.metastore.ingenta.com/content/aip/journal/bmf/7/3/10.1063/1.4804649

Figures

Image of FIG. 1.
FIG. 1.

Storage (red filled squares) and loss (red empty squares) moduli of whole human blood with Hct = 44% determined by passive microrheology at T = 27 °C, within the viscoelastic linear range.

Image of FIG. 2.
FIG. 2.

Storage (red filled squares) and loss (red empty squares) moduli of blood from Figure 1 rescaled to 37 °C using time-temperature superposition, and the fits to multi-mode Giesekus (solid line) and sPTT (blue dots) models. Figure inset shows comparison between the steady shear viscosity curve of whole real blood (red circles) obtained experimentally by Valant and the model fits.

Image of FIG. 3.
FIG. 3.

Viscosity curves for the four analogue solutions in comparison with the viscosity curves of whole human blood of Valant (average between F1 and M3 samples and error bars representing the standard deviation of their averaged values) and Thurston's data. For the analogue solutions open and closed symbols denote measurements with parallel plates and cone-plate, respectively.

Image of FIG. 4.
FIG. 4.

Storage (, closed symbols) and loss (, open symbols) moduli measured by passive microrheology. Comparison between data for the blood analogue solutions at 20 °C and data for real blood (Hct = 44%) shifted to 37 °C. For real blood the results shown are the average of three measurements. The error bars correspond to differences at P < 0.05 (Student's -test).

Image of FIG. 5.
FIG. 5.

Microscope images in the middle plane of a PDMS milli-channel with circular cross-section (top) and micro-channel of rectangular cross-section (bottom) filled with solutions with different refractive index: 1.33 (left), 1.39 (middle), and 1.41 (right) containing 15.47 m spherical particles (refractive index of PDMS was 1.41).

Tables

Generic image for table
Table I.

Parameters of the multi-mode Giesekus and sPTT model fits for whole human blood.

Generic image for table
Table II.

Composition of blood analogues and refractive index. The concentration of DMSO and sucrose is given in wt.% in distilled water.

Generic image for table
Table III.

Relaxation times (λ) obtained from CaBER for the four analogues solutions at room temperature.

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/content/aip/journal/bmf/7/3/10.1063/1.4804649
2013-05-17
2014-04-24
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Viscoelasticity of blood and viscoelastic blood analogues for use in polydymethylsiloxane in vitro models of the circulatory system
http://aip.metastore.ingenta.com/content/aip/journal/bmf/7/3/10.1063/1.4804649
10.1063/1.4804649
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