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High-throughput inertial particle focusing in a curved microchannel: Insights into the flow-rate regulation mechanism and process model
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View: Figures


Image of FIG. 1.
FIG. 1.

(a) Schematic of inertial particle focusing in a spiral microchannel. Particles that are randomly dispersed in the inlet region gradually form a well-ordered particle stream at a specific lateral position while migrating towards the outlets. (b)Photograph of the finished PDMS microfluidic device (the channel of which was filled with red ink for visualization). The inset (i) shows a microscope image of the channel cross-section.

Image of FIG. 2.
FIG. 2.

(a) Fluorescent stream images illustrating the focusing behaviors of two particles in the outlet region at different flow rates. (b) Fluorescence intensity distributions across the channel width at flow rates where the instability occurs. (c)Lateral focusing position as a function of ; and gap between the main and minor focusing positions of 10 m particles.

Image of FIG. 3.
FIG. 3.

(a) Fluorescent stream images captured at various flow rates and the corresponding fluorescence intensities across the channel width, illustrating the interchange process of focusing positions of the two particles. Red solid arrow indicates the focusing position of 5 m particles (the fluorescent streams of these particles are artificially pseudo-colored in red for enhanced contrast); green solid arrow indicates the main focusing position of 10 m particles; and green hollow arrow indicates the minor position of 10 m particles. (b) Focusing ratio as a function of . The inset (i) shows the Gaussian fitting of the fluorescence intensity distribution of 10 m particle stream at  = 4.31.

Image of FIG. 4.
FIG. 4.

(a) Schematic of the developed five-stage process model. (b) Detailed stage distribution of the two particles.

Image of FIG. 5.
FIG. 5.

(a) Schematic of inertial migration of zymosan bioparticles, fluorescent stream images captured near the bifurcated outlets and curves illustrating fluorescence intensity distribution across the channel width. The red line in the stream image of  = 0.86 indicates the specific position for measuring fluorescence intensity. (b) Dark-field microscope images of specimens sampled from the initial suspension and of collected samples after the enrichment operation at the flow rate of  = 12.08. The inset in sample three is an enlarged image showing the debris collected from the outer outlet. 2 m polystyrene particles were artificially added into the initial suspension for size reference.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: High-throughput inertial particle focusing in a curved microchannel: Insights into the flow-rate regulation mechanism and process model