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Sorting of circulating tumor cells (MV3-melanoma) and red blood cells using non-inertial lift
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Image of FIG. 1.
FIG. 1.

Schematic drawing showing the sorting device and the sorting principle. The cells are introduced into the microchannel through the sample inlet with a volume flow rate Q = 20 l/h and focused to the lower channel wall by sheath flows Q = 180 l/h, 380 l/h, and 580 l/h. While moving along the main channel the cells migrate across the streamlines between x and x. This non-inertial lift leads to different heights of the cells at x. The broadening of the channel enhances this height difference and enables cell sorting into outlet 1 and outlet 2.

Image of FIG. 2.
FIG. 2.

Experimental setup for non-inertial lift induced cell sorting. The syringes are driven by two independent syringe pumps. Videos are recorded to analyze the sorting performance of the device.

Image of FIG. 3.
FIG. 3.

Overlays of five consecutive images with a time step dt = 8 ms at x (a), x (b), and x (c) with the corresponding height distributions of MV3-cells and RBCs along the channel. Note the different scale for (c) with respect to (a) and (b). MV3-cells sorted in upper outlet, RBC sorted in lower outlet (Q = 600 l/h, Hct = 4%, η = 7 mPas).

Image of FIG. 4.
FIG. 4.

Sorting efficiencies of MV3-melanoma cells at all parameter sets. The trends for the sorting efficiency are clearly visible: increasing sorting efficiency with increasing flow rate and decreasing efficiency with increasing hematocrit.


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Table I.

Sorting efficiency of MV3-cells under various hematocrits and flow rates. In general, it increases with the sheath flow rate and decreases with the hematocrit.

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Table II.

Overview of sorting efficiency, sorting purity, and enrichment of MV3s and RBCs at all measured parameter sets.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Sorting of circulating tumor cells (MV3-melanoma) and red blood cells using non-inertial lift