(a) Sketch of a microfluidic device showing the droplet generating function, the merging function, the s-channel, and the chambers; (b) photo of a fabricated device; (c) close-up of the T-shape droplet generator; (d) close-up of the merging function; (e) close-up of some chambers; (f) the equivalent fluidic circuit of the device; (g) close-up of a chamber: input size is D1, chamber diameter is D2, and output size is D3.
(a) Procedure to fabricate a DWμC using a LbL nanoassembly process; (b) a sketch showing the controlled drug release: the MnCO3 μP is dissolved by the c-solution and diffuses through the microcapsule; (c) fluorescence images of the DWμCs on a cover slide; (d) the corresponding optical images of the DWμCs (e) optical images of the DWμCs on a cover slide 5 min after adding c-solution; (f) optical images of the DWμCs on a cover slide 10 min after adding c-solution. The size of the MnCO3 μPs is ∼5 μm.
((a)-(c)) Photos showing a drug-laden droplet merged with the c-solution; ((d)-(f)) photos showing the generated droplets switched from the s-channel to the channel leading to the chambers.
(a) Photo showing the chambers occupied by air bubbles or non-uniform droplets obtained using a device without an integrated s-channel; (b) a photo showing each chamber occupied by one droplet using a device with an integrated s-channel. Each droplet blocks the output of the chamber, no other droplet can enter the same chamber. The diameter of all chambers is 120 μm.
(a) Photo showing the DWμCs in a droplet with DI water: no drug release after several days. Photos of the DWμCs in a droplet with the c-solution: (b) 0 min, (c) 2 min, (d) 4 min, clearly showing the dynamic release of the drug from the microcapsules. The diameter of all chambers is 120 μm.
The release rates of the drugs from the microcapsules at different concentrations of the c-solution inside the “simulated” droplets. The concentration of the DWμCs used in these experiments is 2 mg/ml.
Article metrics loading...
Full text loading...