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1. K. Miyata, R. J. Christie, and K. Kataoka, React. Funct. Polym. 71, 227 (2011).
2. J. S. Lee and J. Feijen, J. Controlled Release 161, 473 (2012).
3. T. M. Allen and P. R. Cullis, Adv. Drug Delivery Rev. 65, 36 (2013).
4. V. P. Torchilin, Nat. Rev. Drug Discovery 4, 145 (2005).
5. S. Hauschild, U. Lipprandt, A. Rumplecker, U. Borchert, A. Rank, R. Schubert, and S. Förster, Small 1, 1177 (2005).
6. B. M. Discher, Y.-Y. Won, D. S. Ege, J. C.-M. Lee, F. S. Bates, D. E. Discher, and D. A. Hammer, Science 284, 1143 (1999).
7. C. LoPresti, H. Lomas, M. Massignani, T. Smart, and G. Battaglia, J. Mater. Chem. 19, 3576 (2009).
8. A. Rösler, G. W. M. Vandermeulen, and H.-A. Klok, Adv. Drug Delivery Rev. 64, 270 (2012).
9. J. F. Le Meins, C. Schatz, S. Lecommandoux, and O. Sandre, Mater. Today 16, 397 (2013).
10. M. Chemin, P.-M. Brun, S. Lecommandoux, O. Sandre, and J.-F. Le Meins, Soft Matter 8, 2867 (2012).
11. T. Ruysschaert, A. F. P. Sonnen, T. Haefele, W. Meier, M. Winterhalter, and D. Fournier, J. Am. Chem. Soc. 127, 6242 (2005).
12. A. Olubummo, M. Schulz, B.-D. Lechner, P. Scholtysek, K. Bacia, A. Blume, J. Kressler, and W. H. Binder, ACS Nano 6, 8713 (2012).
13. M. Schulz, D. Glatte, A. Meister, P. Scholtysek, A. Kerth, A. Blume, K. Bacia, and W. H. Binder, Soft Matter 7, 8100 (2011).
14. Z. Cheng and A. Tsourkas, Langmuir 24, 8169 (2008).
15. Z. Cheng, D. R. Elias, N. P. Kamat, E. D. Johnston, A. Poloukhtine, V. Popik, D. A. Hammer, and A. Tsourkas, Bioconjugate Chem. 22, 2021 (2011).
16. J. Nam, P. A. Beales, and T. K. Vanderlick, Langmuir 27, 1 (2011).
17. J. Nam, T. K. Vanderlick, and P. A. Beales, Soft Matter 8, 7982 (2012).
18. N. Pippa, E. Kaditi, S. Pispas, and C. Demetzos, Soft Matter 9, 4073 (2013).
19. T. Bhowmick, E. Berk, X. Cui, V. R. Muzykantov, and S. Muro, J. Controlled Release 157, 485 (2012).
20. O. C. Farokhzad, A. Khademhosseini, S. Jon, A. Hermmann, J. Cheng, C. Chin, A. Kiselyuk, B. Teply, G. Eng, and R. Langer, Anal. Chem. 77, 5453 (2005).
21. C. Fillafer, G. Ratzinger, J. Neumann, Z. Guttenberg, S. Dissauer, I. K. Lichtscheidl, M. Wirth, F. Gabor, and M. F. Schneider, Lab Chip 9, 2782 (2009).
22. T. Fujiwara, H. Akita, K. Furukawa, T. Ushida, H. Mizuguchi, and H. Harashima, Biol. Pharm. Bull. 29, 1511 (2006).
23. S. S. Harris and T. D. Giorgio, Gene Ther. 12, 512 (2005).
24. B. Prabhakarpandian, M.-C. Shen, K. Pant, and M. F. Kiani, Microvasc. Res. 82, 210 (2011).
25. M. Godoy-Gallardo, P. K. Ek, M. M. T. Jansman, B. M. Wohl, and L. Hosta-Rigau, Biomicrofluidics 9, 052605 (2015).
26. B. M. Teo, R. van der Westen, L. Hosta-Rigau, and B. Städler, Biochim. Biophys. Acta, Gen. Subj. 1830, 4838 (2013).
27. L. Hosta-Rigau and B. Städler, Mol. Pharmaceutics 10, 2707 (2013).
28. K. Panneerselvam, S. Mena-Hernando, B. M. Teo, K. N. Goldie, and B. Stadler, RSC Adv. 4, 44769 (2014).
29. L. Castro-Nunez, I. Dienava-Verdoold, E. Herczenik, K. Mertens, and A. B. Meijer, J. Thromb. Haemostasis 10, 1929 (2012).
30. N. Wohner, P. Legendre, C. Casari, O. D. Christophe, P. J. Lenting, and C. V. Denis, J. Thromb. Haemostasis 13, 815 (2015).
31. L. Hosta-Rigau, B. E. B. Jensen, K. S. Fjeldsø, A. Postma, G. Guoxin Li, K. N. Goldie, F. Albericio, A. N. Zelikin, and B. Städler, Adv. Healthcare Mater. 1, 791 (2012).
32. A. C. De Visser, K. De Groot, J. Feyen, and A. Bantjes, J. Polym. Sci., Part A-1: Polym. Chem. 9, 1893 (1971).
33. A. C. de Visser, J. Feyen, K. de Groot, and A. Bantjes, J. Polym. Sci., Part B: Polym. Lett. 8, 805 (1970).
34. F. Delbecq and K. Kawakami, Colloids Surf., A 444, 173 (2014).
35. S.-J. He, Y. Zhang, Z.-H. Cui, Y.-Z. Tao, and B.-L. Zhang, Eur. Polym. J. 45, 2395 (2009).
36. H. Zeng, Y. Li, H. Zhang, and X. Wang, Acta Polym. Sin. 1, 327 (2004).
37. L. Hosta-Rigau, Y. Zhang, B. M. Teo, A. Postma, and B. Stadler, Nanoscale 5, 89 (2013).
38. L. Klouda and A. G. Mikos, Eur. J. Pharm. Biopharm. 68, 34 (2008).
39. E. M. Pelegri-O'Day, E.-W. Lin, and H. D. Maynard, J. Am. Chem. Soc. 136, 14323 (2014).
40.See supplementary material at for the chemical structures, the polymersome assembly, dissipation changes, DLS results of hybrid assemblies, and the uptake efficiencies.[Supplementary Material]

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Recently, the combination of lipids and block copolymers has become an alternative to liposomes and polymersomes as nano-sized drug carriers. We synthesize novel block copolymers consisting of poly(cholesteryl acrylate) as the hydrophobic core and poly(-isopropylacrylamide) (PNIPAAm) as the hydrophilic extensions. Their successful phospholipid-assisted assembly into vesicles is demonstrated using the evaporation-hydration method. The preserved thermo-responsive property of the lipid-polymer hybrids is shown by a temperature dependent adsorption behaviour of the vesicles to poly( lysine) coated surfaces. As expected, the vesicle adsorption is found to be higher at elevated temperatures. The cellular uptake efficiency of hybrids is assessed using macrophages with applied shear stress. The amount of adhering macrophages is affected by the time and level of applied shear stress. Further, it is found that shorter PNIPAAm extensions lead to higher uptake of the assemblies by the macrophages with applied shear stress. No inherent cytotoxicity is observed at the tested conditions. Taken together, this first example of responsive lipid-polymer hybrids, and their positive biological evaluation makes them promising nano-sized drug carrier candidates.


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