Skip to main content
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
/content/aip/journal/bmf/9/5/10.1063/1.4929405
1.
1. K. Miyata, R. J. Christie, and K. Kataoka, React. Funct. Polym. 71, 227 (2011).
http://dx.doi.org/10.1016/j.reactfunctpolym.2010.10.009
2.
2. J. S. Lee and J. Feijen, J. Controlled Release 161, 473 (2012).
http://dx.doi.org/10.1016/j.jconrel.2011.10.005
3.
3. T. M. Allen and P. R. Cullis, Adv. Drug Delivery Rev. 65, 36 (2013).
http://dx.doi.org/10.1016/j.addr.2012.09.037
4.
4. V. P. Torchilin, Nat. Rev. Drug Discovery 4, 145 (2005).
http://dx.doi.org/10.1038/nrd1632
5.
5. S. Hauschild, U. Lipprandt, A. Rumplecker, U. Borchert, A. Rank, R. Schubert, and S. Förster, Small 1, 1177 (2005).
http://dx.doi.org/10.1002/smll.200500093
6.
6. B. M. Discher, Y.-Y. Won, D. S. Ege, J. C.-M. Lee, F. S. Bates, D. E. Discher, and D. A. Hammer, Science 284, 1143 (1999).
http://dx.doi.org/10.1126/science.284.5417.1143
7.
7. C. LoPresti, H. Lomas, M. Massignani, T. Smart, and G. Battaglia, J. Mater. Chem. 19, 3576 (2009).
http://dx.doi.org/10.1039/b818869f
8.
8. A. Rösler, G. W. M. Vandermeulen, and H.-A. Klok, Adv. Drug Delivery Rev. 64, 270 (2012).
http://dx.doi.org/10.1016/j.addr.2012.09.026
9.
9. J. F. Le Meins, C. Schatz, S. Lecommandoux, and O. Sandre, Mater. Today 16, 397 (2013).
http://dx.doi.org/10.1016/j.mattod.2013.09.002
10.
10. M. Chemin, P.-M. Brun, S. Lecommandoux, O. Sandre, and J.-F. Le Meins, Soft Matter 8, 2867 (2012).
http://dx.doi.org/10.1039/c2sm07188f
11.
11. T. Ruysschaert, A. F. P. Sonnen, T. Haefele, W. Meier, M. Winterhalter, and D. Fournier, J. Am. Chem. Soc. 127, 6242 (2005).
http://dx.doi.org/10.1021/ja043600x
12.
12. A. Olubummo, M. Schulz, B.-D. Lechner, P. Scholtysek, K. Bacia, A. Blume, J. Kressler, and W. H. Binder, ACS Nano 6, 8713 (2012).
http://dx.doi.org/10.1021/nn3023602
13.
13. M. Schulz, D. Glatte, A. Meister, P. Scholtysek, A. Kerth, A. Blume, K. Bacia, and W. H. Binder, Soft Matter 7, 8100 (2011).
http://dx.doi.org/10.1039/c1sm05725a
14.
14. Z. Cheng and A. Tsourkas, Langmuir 24, 8169 (2008).
http://dx.doi.org/10.1021/la801027q
15.
15. Z. Cheng, D. R. Elias, N. P. Kamat, E. D. Johnston, A. Poloukhtine, V. Popik, D. A. Hammer, and A. Tsourkas, Bioconjugate Chem. 22, 2021 (2011).
http://dx.doi.org/10.1021/bc200214g
16.
16. J. Nam, P. A. Beales, and T. K. Vanderlick, Langmuir 27, 1 (2011).
http://dx.doi.org/10.1021/la103428g
17.
17. J. Nam, T. K. Vanderlick, and P. A. Beales, Soft Matter 8, 7982 (2012).
http://dx.doi.org/10.1039/c2sm25646k
18.
18. N. Pippa, E. Kaditi, S. Pispas, and C. Demetzos, Soft Matter 9, 4073 (2013).
http://dx.doi.org/10.1039/c3sm27447k
19.
19. T. Bhowmick, E. Berk, X. Cui, V. R. Muzykantov, and S. Muro, J. Controlled Release 157, 485 (2012).
http://dx.doi.org/10.1016/j.jconrel.2011.09.067
20.
20. O. C. Farokhzad, A. Khademhosseini, S. Jon, A. Hermmann, J. Cheng, C. Chin, A. Kiselyuk, B. Teply, G. Eng, and R. Langer, Anal. Chem. 77, 5453 (2005).
http://dx.doi.org/10.1021/ac050312q
21.
21. C. Fillafer, G. Ratzinger, J. Neumann, Z. Guttenberg, S. Dissauer, I. K. Lichtscheidl, M. Wirth, F. Gabor, and M. F. Schneider, Lab Chip 9, 2782 (2009).
http://dx.doi.org/10.1039/b906006e
22.
22. T. Fujiwara, H. Akita, K. Furukawa, T. Ushida, H. Mizuguchi, and H. Harashima, Biol. Pharm. Bull. 29, 1511 (2006).
http://dx.doi.org/10.1248/bpb.29.1511
23.
23. S. S. Harris and T. D. Giorgio, Gene Ther. 12, 512 (2005).
http://dx.doi.org/10.1038/sj.gt.3302397
24.
24. B. Prabhakarpandian, M.-C. Shen, K. Pant, and M. F. Kiani, Microvasc. Res. 82, 210 (2011).
http://dx.doi.org/10.1016/j.mvr.2011.06.013
25.
25. M. Godoy-Gallardo, P. K. Ek, M. M. T. Jansman, B. M. Wohl, and L. Hosta-Rigau, Biomicrofluidics 9, 052605 (2015).
http://dx.doi.org/10.1063/1.4923324
26.
26. B. M. Teo, R. van der Westen, L. Hosta-Rigau, and B. Städler, Biochim. Biophys. Acta, Gen. Subj. 1830, 4838 (2013).
http://dx.doi.org/10.1016/j.bbagen.2013.06.022
27.
27. L. Hosta-Rigau and B. Städler, Mol. Pharmaceutics 10, 2707 (2013).
http://dx.doi.org/10.1021/mp4001298
28.
28. K. Panneerselvam, S. Mena-Hernando, B. M. Teo, K. N. Goldie, and B. Stadler, RSC Adv. 4, 44769 (2014).
http://dx.doi.org/10.1039/C4RA07720B
29.
29. L. Castro-Nunez, I. Dienava-Verdoold, E. Herczenik, K. Mertens, and A. B. Meijer, J. Thromb. Haemostasis 10, 1929 (2012).
http://dx.doi.org/10.1111/j.1538-7836.2012.04860.x
30.
30. N. Wohner, P. Legendre, C. Casari, O. D. Christophe, P. J. Lenting, and C. V. Denis, J. Thromb. Haemostasis 13, 815 (2015).
http://dx.doi.org/10.1111/jth.12885
31.
31. L. Hosta-Rigau, B. E. B. Jensen, K. S. Fjeldsø, A. Postma, G. Guoxin Li, K. N. Goldie, F. Albericio, A. N. Zelikin, and B. Städler, Adv. Healthcare Mater. 1, 791 (2012).
http://dx.doi.org/10.1002/adhm.201200092
32.
32. A. C. De Visser, K. De Groot, J. Feyen, and A. Bantjes, J. Polym. Sci., Part A-1: Polym. Chem. 9, 1893 (1971).
http://dx.doi.org/10.1002/pol.1971.150090709
33.
33. A. C. de Visser, J. Feyen, K. de Groot, and A. Bantjes, J. Polym. Sci., Part B: Polym. Lett. 8, 805 (1970).
http://dx.doi.org/10.1002/pol.1970.110081110
34.
34. F. Delbecq and K. Kawakami, Colloids Surf., A 444, 173 (2014).
http://dx.doi.org/10.1016/j.colsurfa.2013.12.057
35.
35. S.-J. He, Y. Zhang, Z.-H. Cui, Y.-Z. Tao, and B.-L. Zhang, Eur. Polym. J. 45, 2395 (2009).
http://dx.doi.org/10.1016/j.eurpolymj.2009.04.030
36.
36. H. Zeng, Y. Li, H. Zhang, and X. Wang, Acta Polym. Sin. 1, 327 (2004).
37.
37. L. Hosta-Rigau, Y. Zhang, B. M. Teo, A. Postma, and B. Stadler, Nanoscale 5, 89 (2013).
http://dx.doi.org/10.1039/C2NR32923A
38.
38. L. Klouda and A. G. Mikos, Eur. J. Pharm. Biopharm. 68, 34 (2008).
http://dx.doi.org/10.1016/j.ejpb.2007.02.025
39.
39. E. M. Pelegri-O'Day, E.-W. Lin, and H. D. Maynard, J. Am. Chem. Soc. 136, 14323 (2014).
http://dx.doi.org/10.1021/ja504390x
40.
40.See supplementary material at http://dx.doi.org/10.1063/1.4929405 for the chemical structures, the polymersome assembly, dissipation changes, DLS results of hybrid assemblies, and the uptake efficiencies.[Supplementary Material]
http://aip.metastore.ingenta.com/content/aip/journal/bmf/9/5/10.1063/1.4929405
Loading
/content/aip/journal/bmf/9/5/10.1063/1.4929405
Loading

Data & Media loading...

Loading

Article metrics loading...

/content/aip/journal/bmf/9/5/10.1063/1.4929405
2015-08-24
2016-09-29

Abstract

Recently, the combination of lipids and block copolymers has become an alternative to liposomes and polymersomes as nano-sized drug carriers. We synthesize novel block copolymers consisting of poly(cholesteryl acrylate) as the hydrophobic core and poly(-isopropylacrylamide) (PNIPAAm) as the hydrophilic extensions. Their successful phospholipid-assisted assembly into vesicles is demonstrated using the evaporation-hydration method. The preserved thermo-responsive property of the lipid-polymer hybrids is shown by a temperature dependent adsorption behaviour of the vesicles to poly( lysine) coated surfaces. As expected, the vesicle adsorption is found to be higher at elevated temperatures. The cellular uptake efficiency of hybrids is assessed using macrophages with applied shear stress. The amount of adhering macrophages is affected by the time and level of applied shear stress. Further, it is found that shorter PNIPAAm extensions lead to higher uptake of the assemblies by the macrophages with applied shear stress. No inherent cytotoxicity is observed at the tested conditions. Taken together, this first example of responsive lipid-polymer hybrids, and their positive biological evaluation makes them promising nano-sized drug carrier candidates.

Loading

Full text loading...

/deliver/fulltext/aip/journal/bmf/9/5/1.4929405.html;jsessionid=kk66xmzJq4IbJN3sDt7lUfAE.x-aip-live-03?itemId=/content/aip/journal/bmf/9/5/10.1063/1.4929405&mimeType=html&fmt=ahah&containerItemId=content/aip/journal/bmf
true
true

Access Key

  • FFree Content
  • OAOpen Access Content
  • SSubscribed Content
  • TFree Trial Content
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
/content/realmedia?fmt=ahah&adPositionList=
&advertTargetUrl=//oascentral.aip.org/RealMedia/ads/&sitePageValue=bmf.aip.org/9/5/10.1063/1.4929405&pageURL=http://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4929405'
Right1,Right2,Right3,