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An investigation of models of the channel in Xenopus oocyte
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10.1063/1.3156402
/content/aip/journal/chaos/19/3/10.1063/1.3156402
http://aip.metastore.ingenta.com/content/aip/journal/chaos/19/3/10.1063/1.3156402

Figures

Image of FIG. 1.
FIG. 1.

Model 1: (a) The structure of the De Young–Keizer subunit model. The graph shows the dependence of (b) the open probability , (c) the mean open time , and (d) the mean close time as a function of concentration for different concentrations of . The lines show the results calculated with the deterministic transition matrix theory and the symbols show the results obtained from single-channel patch clamp from on native nuclear membranes (Refs. 11–13 ). Here, thick lines and stars are for , thin lines and circles are for , dashed lines and squares are for , and dotted lines and triangles are for . Same notations are used in the following figures. The parameters used in the model are , , , , , , , and .

Image of FIG. 2.
FIG. 2.

Model 2: (a) The subunit structure of the channel model, (b) the open probability , (c) the mean open time , and (d) the mean close time . In the model , , , , , , , and .

Image of FIG. 3.
FIG. 3.

Model 3: (a) The subunit structure of the channel model. A conformational transition to an active state (state- ) occurs before the subunit can contribute to channel opening. (b) The open probability , (c) the mean open time , and (d) the mean close time . In the model , , , , and . For the conformational change, and .

Image of FIG. 4.
FIG. 4.

Model 4: (a) The subunit structure of the channel model, (b) the open probability , (c) the mean open time , and (d) the mean close time . In the model , , , , , and with .

Image of FIG. 5.
FIG. 5.

Model 5: (a) The subunit structure of the channel model, (b) the open probability , (c) the mean open time , and (d) the mean close time . In the model , , , , , and with .

Image of FIG. 6.
FIG. 6.

Model 6: (a) The state structure of the sequential binding model, (b) the open probability , (c) the mean open time , and (d) the mean close time . In (c), the mean open time is independent of concentration. In the model , , , , , , , and .

Image of FIG. 7.
FIG. 7.

Model 7: (a) The state structure of the sequential binding model, (b) the open probability , (c) the mean open time , and (d) the mean close time . In the model , , , , , and with .

Image of FIG. 8.
FIG. 8.

Model 8: (a) The state structure of the sequential binding model, (b) the open probability , and (c) the mean close time . The inset figure in (c) is the plot of the mean open time . In the model , , , , , and with .

Tables

Generic image for table
Table I.

The mismatch value for fitting of the eight models. Here the value has been rescaled by the averaged open probability of the channel for the experimental data.

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/content/aip/journal/chaos/19/3/10.1063/1.3156402
2009-09-18
2014-04-23
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: An investigation of models of the IP3R channel in Xenopus oocyte
http://aip.metastore.ingenta.com/content/aip/journal/chaos/19/3/10.1063/1.3156402
10.1063/1.3156402
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