No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer
1.P. Rennie, J. Read, and L. Murphy, in The Basic Science of Oncology, edited by I. F. Tannock, R. P. Hill, R. G. Bristow, and L. Harrington (McGraw-Hill, New York, 2005).
9.S. Malone, G. Perry, L. Eapen, R. Segal, V. Gallant, S. Dahrouge, J. Crook, and J. N. Spaans, Int. J. Radiat. Oncol., Biol., Phys. 68, 699 (2007).
Article metrics loading...
We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.
Full text loading...
Most read this month