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Fibroblasts alter spiral wave stability
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10.1063/1.3527996
/content/aip/journal/chaos/20/4/10.1063/1.3527996
http://aip.metastore.ingenta.com/content/aip/journal/chaos/20/4/10.1063/1.3527996
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

The structure of the three-domain system consisting of the myocyte domain, the fibroblast domain and the extracellular space. The currents flowing between domains provide coupling between them. are the stimulation currents.

Image of FIG. 2.
FIG. 2.

Adopted from Weiss et al. (Ref. 3): During pacing at a fixed cycle length , a premature stimulus is introduced at progressively shorter DIs. APD progressively shortens as DI decreases until the cell is refractory.

Image of FIG. 3.
FIG. 3.

Restitution curve (square markers) for , and (a) (no fibroblasts) and (b) , , (with fibroblasts). Black line: . The influence of fibroblasts makes the spiral wave with the period of 200 ms unstable.

Image of FIG. 4.
FIG. 4.

Restitution curve (square markers) for , and (a) (no fibroblasts) and (b) , , (with fibroblasts). Black line: . The influence of fibroblasts stabilizes the spiral wave with the period of 200 ms.

Image of FIG. 5.
FIG. 5.

The map multiplier depending on the asymmetry . Blue curve with square markers: , , . Dark red curve with circle markers: , , . Vertical dashed line—the border of too strong influence from fibroblasts on myocytes causing the block of excitation. Horizontal dashed line—the boarder of stability.

Image of FIG. 6.
FIG. 6.

The snapshots of myocyte transmembrane voltage. (a) Stable spiral in the absence of fibroblasts , time moments (from left to right): 50, 350, 650, and 5000 ms; (b) instability of the spiral caused by the fibroblasts with , time moments: 50, 350, 650, and 2500 ms; (c) unstable spiral in the absence of fibroblasts , time moments: 50, 500, 900, and 4500 ms; (d) the spiral stabilized by the fibroblasts with , time moments: 50, 500, 2000, and 5000 ms.

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/content/aip/journal/chaos/20/4/10.1063/1.3527996
2010-12-30
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Fibroblasts alter spiral wave stability
http://aip.metastore.ingenta.com/content/aip/journal/chaos/20/4/10.1063/1.3527996
10.1063/1.3527996
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