No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
Resynchronization of circadian oscillators and the east-west asymmetry of jet-lag
Y. Yamaguchi, T. Suzuki, Y. Mizoro, H. Kori, K. Okada, Y. Chen, J.-M. Fustin, F. Yamazaki, N. Mizuguchi, J. Zhang et al., Science 342, 85 (2013).
S. S. Campbell, D. Dawson, and J. Zulley, Sleep 16, 638 (1993).
C. A. Czeisler, J. F. Duffy, T. L. Shanahan, E. N. Brown, J. F. Mitchell, D. W. Rimmer, J. M. Ronda, E. J. Silva, J. S. Allan, J. S. Emens et al., Science 284, 2177 (1999).
S. A. Brown, F. Fleury-Olela, E. Nagoshi, C. Hauser, C. Juge, C. A. Meier, R. Chicheportiche, J.-M. Dayer, U. Albrecht, and U. Schibler, PLoS Biol 3, e338 (2005).
J. Aschoff, K. Hoffmann, H. Pohl, and R. Wever, Chronobiologia 2, 23 (1974).
T. Takahashi, M. Sasaki, H. Itoh, H. Sano, W. Yamadera, M. Ozone, K. Obuchi, H. Nishimura, and N. Matsunaga, Psychiatry Clin. Neurosci. 53, 257 (1999).
T. Takahashi, M. Sasaki, H. Itoh, W. Yamadera, M. Ozone, K. Obuchi, N. Matsunaga, H. Sano, and K.-I. Hayashida, Psychiatry Clin. Neurosci. 55, 275 (2001).
R. A. Wever, The Circadian System of Man: Results of Experiments Under Temporal Isolation ( Springer Science & Business Media, 2013).
We also explored cases with an average oscillator period of 24.2 h consistent with Ref. 25. However, with this smaller period it was not possible to find a set of the other parameters of the model system (K, F, Δ) that simultaneously yielded results approximately consistent with empirical studies. If the 24.2 h results of Ref. 25 actually applies, the above may indicate that our model is too simple to be trusted for quantitative prediction.
Article metrics loading...
Cells in the brain's Suprachiasmatic Nucleus (SCN) are known to regulate circadian rhythms in mammals. We model synchronization of SCN cells using the forced Kuramoto model, which consists of a large population of coupled phase oscillators
(modeling individual SCN cells) with heterogeneous intrinsic frequencies and external periodic forcing. Here, the periodic forcing models diurnally varying external inputs such as sunrise, sunset, and alarm clocks. We reduce the dimensionality of the system using the ansatz of Ott and Antonsen and then study the effect of a sudden change of clock phase to simulate cross-time-zone travel. We estimate model parameters from previous biological experiments. By examining the phase space dynamics of the model, we study the mechanism leading to the difference typically experienced in the severity of jet-lag resulting from eastward and westward travel.
Full text loading...
Most read this month