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Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging
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A targeted goldnanoparticle has been developed as a contrast agent for photoacousticmedical imaging. We have studied cancer cell targeting by antibody conjugated goldnanorods for high contrastphotoacoustic imaging. By changing the aspect ratio of the elongated “rod” shape of the goldnanoparticle, its plasmon peak absorption wavelength can be tuned to the near IR for an increased penetration depth into biological tissue. Effective cell targeting and sensitive photoacoustic detection of a single layer of cells are demonstrated. Combining ultrasound with contrast agent based photoacoustic imaging is proposed as a visual tool to compound molecular and structural information for early stage prostate cancer detection.
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