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Effects of diffusion boundary layer on reaction kinetics of immunoassay in a biosensor
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10.1063/1.2909980
/content/aip/journal/jap/103/8/10.1063/1.2909980
http://aip.metastore.ingenta.com/content/aip/journal/jap/103/8/10.1063/1.2909980
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Sketch of the 2D model. The size of the biosensor is in length and in thickness. The channel size is in length and in height.

Image of FIG. 2.
FIG. 2.

2D unstructured mesh with triangular elements.

Image of FIG. 3.
FIG. 3.

The average surface concentration of CRP-anti-CRP complex along the surface as a function of time for different CRP bulk concentrations.

Image of FIG. 4.
FIG. 4.

The average surface concentration of IgG-anti-IgG complex along the surface as a function of time for different IgG bulk concentrations.

Image of FIG. 5.
FIG. 5.

The saturated concentration of analyte-ligand complex as a function of the concentration of analyte in the bulk.

Image of FIG. 6.
FIG. 6.

The development of the diffusion boundary layer of the CRP binding reaction. The biosensor is located at (250, 1.5) and the concentration of CRP is . The left three illustrations are in association phase at times of 500, 1000, and , and the right three illustrations are in dissociation phase at times of 3000, 4000, and . Notice that the density scales are different to increase the plot visibility.

Image of FIG. 7.
FIG. 7.

The development of the diffusion boundary layer of the IgG binding reaction. The biosensor is located at (250, 1.5) and the inlet concentration of IgG is . The left three illustrations are in association phase at times of 1000, 2000, and , and the right three illustrations are in dissociation phase at times 6000, 7000, and . Notice that the density scales are different to increase the plot visibility.

Image of FIG. 8.
FIG. 8.

Influence of raising the inlet flow velocity on the curve of the surface concentration of CRP complex vs time. Notice that the biosensor is located at (250, 1.5) and the inlet concentration of CRP is .

Image of FIG. 9.
FIG. 9.

The initial slope of CRP binding reaction as a function of channel’s height. The inlet concentration of CRP is . The channel’s inlet flow velocity is .

Image of FIG. 10.
FIG. 10.

The initial slope of IgG binding reaction as a function of channel’s height. The inlet concentration of IgG is . The channel’s inlet flow velocity is .

Image of FIG. 11.
FIG. 11.

The average surface concentration of CRP complex along the surface as a function of time for various lengths of the reaction surface. The concentration of CRP is . The channel’s inlet flow velocity is . The size of the channel is shown in Fig. 1.

Image of FIG. 12.
FIG. 12.

The expansion of the diffusion boundary layer for varying lengths of the reaction surface. It is noticed that the for (a) , (b) , (c) , (d) , (e) , and (f) , respectively.

Image of FIG. 13.
FIG. 13.

Sketch of the 3D model. The channel size is in length, in width, and in height. The biosensor, in length, in height, and variable width, is put on the center of the bottom surface.

Image of FIG. 14.
FIG. 14.

The average surface concentration of CRP-anti-CRP complex along the surface as a function of time for the reaction surface with various widths.

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/content/aip/journal/jap/103/8/10.1063/1.2909980
2008-04-28
2014-04-18
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Effects of diffusion boundary layer on reaction kinetics of immunoassay in a biosensor
http://aip.metastore.ingenta.com/content/aip/journal/jap/103/8/10.1063/1.2909980
10.1063/1.2909980
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