1887
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
Refracting Röntgen’s rays: Propagation-based x-ray phase contrast for biomedical imaging
Rent:
Rent this article for
USD
10.1063/1.3115402
/content/aip/journal/jap/105/10/10.1063/1.3115402
http://aip.metastore.ingenta.com/content/aip/journal/jap/105/10/10.1063/1.3115402
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

(a) Generic setup for absorption-contrast imaging, in which a large x-ray source illuminates an object so as to form an absorption-contrast image over the surface of a detector . The dashed lines show the increase in penumbral blurring that arises from increasing in this setup (b) Generic setup for phase-contrast imaging, in which a small x-ray source illuminates an object so as to form a propagation-based phase-contrast image over the surface of a detector .

Image of FIG. 2.
FIG. 2.

Simulated propagation-based phase-contrast images of a solid carbon sphere of radius 0.25 mm, corresponding to x-ray wavelength 0.5 Å, and source-to-object distance . Phase-contrast images are calculated as a function of object-to-detector distance , for a variety of different source diameters .

Image of FIG. 3.
FIG. 3.

Contrast , defined using Eq. (1), for phase-contrast images of a solid carbon sphere of radius 0.25 mm. Here, source-to-object distance , x-ray wavelength , with source diameter and object-to-detector distance both being variable.

Image of FIG. 4.
FIG. 4.

Typical contrast at the phase edge (a). Dependences of the effective Fresnel number [Eq. (14)] (b), SNR [Eq. (15)] (c), and image width of the edge (d) on the geometrical magnification . The following parameters of the phase edge and the experimental conditions have been used in numerical calculations: , , (20 keV), , [the legend shown in Fig. 4(b) is also applied to Figs. 4(c) and 4(d)].

Image of FIG. 5.
FIG. 5.

Calculated complex x-ray refractive-index decrements and as a function of x-ray energy (log-log plot) for cortical bone and breast tissue. For the contributions from photoelectric (p.e.), coherent (coh.), and incoherent (incoh.) cross sections are included as well as the total. The photoelectric contributions are indicated by arrows for clarity.

Image of FIG. 6.
FIG. 6.

Propagation-based phase-contrast x-ray image of a section of a human finger bone (proximal phalanx). The image was recorded using a Feinfocus microfocus x-ray source with W target and Fuji high-resolution imaging plate ( size). The experimental conditions were as follows: 30 kVp, 38 mAs (x-ray spot size approximately ); , . The raw data have been subjected to “unsharp masking” and is presented as a “positive,” i.e., black regions correspond to lower x-ray flux. The field of view corresponds to approximately square, and the insert to square. The finest visible features are approximately in size.

Image of FIG. 7.
FIG. 7.

Propagation-based phase-contrast x-ray image of a fixed, excised mouse kidney. The image was recorded using a Feinfocus microfocus x-ray source with W target and Fuji high-resolution imaging plate ( size). The experimental conditions were as follows: 30 kVp, 3 mAs (x-ray spot size approximately ); , . The raw data have been subjected to unsharp masking and is presented as a positive. The field of view corresponds to approximately 11.5 mm horizontally, and the insert to square. The finest visible features are approximately in size.

Image of FIG. 8.
FIG. 8.

Propagation-based phase-contrast x-ray image of a sample of blood cells stained with osmium tetroxide and uranyl acetate. The image was recorded using an XuM which has an x-ray source size of approximately 100 nm. The image was acquired with a 15 kV accelerating voltage on a thin Ta foil target, using a direct-detection charge-coupled device. The field of view corresponds to approximately . The finest visible features are approximately . The profile corresponds to the x-ray flux across the horizontal line shown.

Loading

Article metrics loading...

/content/aip/journal/jap/105/10/10.1063/1.3115402
2009-05-19
2014-04-21
Loading

Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Refracting Röntgen’s rays: Propagation-based x-ray phase contrast for biomedical imaging
http://aip.metastore.ingenta.com/content/aip/journal/jap/105/10/10.1063/1.3115402
10.1063/1.3115402
SEARCH_EXPAND_ITEM