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Fabrication and characterization of a porous silicon based microarray for label-free optical monitoring of biomolecular interactions
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10.1063/1.3273410
/content/aip/journal/jap/107/1/10.1063/1.3273410
http://aip.metastore.ingenta.com/content/aip/journal/jap/107/1/10.1063/1.3273410
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Technological steps of the PSi microarray fabrication process.

Image of FIG. 2.
FIG. 2.

Scheme of the functionalization process of the PSi microarray surface, from the Piranha incubation to the covalent attachment of the DNA single strand.

Image of FIG. 3.
FIG. 3.

(a) Optical microscope images of the Bragg reflectors microarray; in the inset, a zoom on few elements with the diameter measurement. (b) SEM characterization of one microchamber. In the first inset, a particular of the microchamber wall and the silicon nitride mask layer. In the second inset the structure of the porous layers.

Image of FIG. 4.
FIG. 4.

Reflectivity spectra of the PSi Bragg reflectors.

Image of FIG. 5.
FIG. 5.

FTIR spectrum of the PSi surface after the functionalization process.

Image of FIG. 6.
FIG. 6.

(a) Reflectivity spectra of the Bragg reflectors before and after the thermal oxidation process, after the APTES and GA functionalization, and after the DNA probe attachment. (b) The correspondent optical microscope images of the Bragg reflectors microarray.

Image of FIG. 7.
FIG. 7.

(a) Reflectivity spectra of a PSi Bragg reflector element before (black line) and after (red line) the interaction with noncomplementary DNA, and after (green line) the hybridization with the complementary single-stranded DNA. (b) The correspondent optical microscope images.

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/content/aip/journal/jap/107/1/10.1063/1.3273410
2010-01-12
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Fabrication and characterization of a porous silicon based microarray for label-free optical monitoring of biomolecular interactions
http://aip.metastore.ingenta.com/content/aip/journal/jap/107/1/10.1063/1.3273410
10.1063/1.3273410
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