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Drug injection into fat tissue with a laser based microjet injector
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View: Figures


Image of FIG. 1.
FIG. 1.

(Color online) The schematic of the experimental setup for generating a bubble in distilled water.

Image of FIG. 2.
FIG. 2.

The sequential images of a bubble induced by a laser pulse with 35 mJ. The bubble reached its maximum radius of about 0.5 mm at 50 μs, and it collapsed at 95 μs.

Image of FIG. 3.
FIG. 3.

(Color online) Illustration of the sequential mechanisms of the laser based microjet generation. The first shockwave, which propagates toward the nozzle end, drives the first microjet. Then, an explosive growth of vapor bubbles, which is triggered by the optical breakdown in water, causes elastic deformation of membrane, pushing the second microjet. Afterwards, another shockwave is induced by a bubble collapse with the third microjet injected.

Image of FIG. 4.
FIG. 4.

(Color online) The images of microjet creation with a 314 mJ of infrared laser pulse. Numbers on the left indicates the time elapsed after the first image. The black region on the right is the nozzle surface, and microjets are emerged from the nozzle exit at the center.

Image of FIG. 5.
FIG. 5.

(Color online) Penetrated pork fat. Water-based black ink was injected into the pork fat tissue with 3 J of pulse energy. (a) top view of the penetrated target; the hole diameter was about 150 μm. (b) cross sectional view of the target; the penetrated depth and width were about 750 and 100 μm, respectively.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Drug injection into fat tissue with a laser based microjet injector