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Mode-splitting-based optical label-free biosensing with a biorecognition-covered microcavity
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View: Figures


Image of FIG. 1.
FIG. 1.

(a) Mode function depending on the angle θ defined in the inset. Inset: Cross-section mode distribution of a fundamental TE mode obtained from numerical simulation. (b) Three-dimensional structure and a simplified model of IgG antibody. The length of each rod is about 8 nm, and the diameter is 3 nm. The average angle between the two Fabs is 127°.

Image of FIG. 2.
FIG. 2.

(a) Frequency splitting induced by the antibody vs. the surface covering ratio ζ, where σ is the standard deviation. (b) Critical cavity Q-factor for different surface coating ratio. In the upper left area of the curve, no splitting appears before adsorption of biological targets, while in the lower right area, a mode splitting is resolved after antibody coating procedure.

Image of FIG. 3.
FIG. 3.

(a) Measured radius of spherical nanoparticle vs. actual radius when the pre-covering ratio ζ = 0.5. (b) Relative standard error for nanoparticle sizing depending on its radius and the different surface covering ratio ζ.

Image of FIG. 4.
FIG. 4.

Ratio of linewidth broadening induced by absorption and scattering losses depending on the radius of target nanoparticle.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Mode-splitting-based optical label-free biosensing with a biorecognition-covered microcavity