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In-vivo visualization of melanoma tumor microvessels and blood flow velocity changes accompanying tumor growth
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10.1063/1.4766815
/content/aip/journal/jap/112/10/10.1063/1.4766815
http://aip.metastore.ingenta.com/content/aip/journal/jap/112/10/10.1063/1.4766815
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Schematic diagram showing μ-MLDV and test samples used: (a) optical components, (b) scanning direction in linear measurement region, (c) blood vessel pattern, (d) schematic of cross-section.

Image of FIG. 2.
FIG. 2.

Flowchart of software used to determine flow velocity. Time series data for 1 s are partitioned into sections containing 244 data points. Flow velocities are calculated for each section, but sections that do not satisfy the three validation criteria are omitted. The output flow velocity is the average value for all sections that satisfy the three validation criteria.

Image of FIG. 3.
FIG. 3.

Time courses of lesion development over 16 days after transplantation: (a) before transplantation; (b) lesion was not identified two days after transplantation; (c) lesion area is 0.57 mm2 at five days; (d) 2.2 mm2 at nine days; (e) 6.6 mm2 at 12 days, and (f) 18 mm2 at 16 days.

Image of FIG. 4.
FIG. 4.

Blood flow velocity images corresponding to photographs in Fig. 3: (a) before transplantation and (b) two, (c) five, (d) nine, (e) 12, and (f) 16 days after transplantation. Flow velocities are expressed by 30-level color scale. Measurement was performed when heart rate was 240–250 beats/s.

Image of FIG. 5.
FIG. 5.

Variation in maximum flow velocity as a function of elapsed time after transplantation. The maximum flow velocities were measured at the points indicated by the asterisks in the blood flow velocity images of Figs. 4(a)–4(f).

Image of FIG. 6.
FIG. 6.

Blood flow images obtained by laser speckle system: (a) before transplantation and (b) 12 days after transplantation. Flow velocities are expressed by 16-level color scale. Measurements were performed when the heart rate was 240–250 beats/s.

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/content/aip/journal/jap/112/10/10.1063/1.4766815
2012-11-26
2014-04-20
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: In-vivo visualization of melanoma tumor microvessels and blood flow velocity changes accompanying tumor growth
http://aip.metastore.ingenta.com/content/aip/journal/jap/112/10/10.1063/1.4766815
10.1063/1.4766815
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