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Dynamics of vesicle self-assembly and dissolution
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10.1063/1.2358983
/content/aip/journal/jcp/125/16/10.1063/1.2358983
http://aip.metastore.ingenta.com/content/aip/journal/jcp/125/16/10.1063/1.2358983
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

(Color online) Membrane viscosity as a function of for two values of the surface tension, and , as indicated.

Image of FIG. 2.
FIG. 2.

Snapshots of different stages of the self-assembly process in a BD simulation at the density of membrane particles , with and . (a) , (b) , and (c) .

Image of FIG. 3.
FIG. 3.

(Color online) Time development of the mean cluster size for self-assembly at . The solid lines represent data for , 0.0076, and 0.015 (from bottom to top) without hydrodynamic interactions (BD). The dashed lines represent data for with hydrodynamic interactions (MPC). Error bars are shown at several data points.

Image of FIG. 4.
FIG. 4.

(Color online) Time development of the average number of clusters for , , and , in a system without hydrodynamic interactions (BD). The solid and dashed lines represent the number of vesicles and the other clusters, respectively. Error bars are shown at several data points.

Image of FIG. 5.
FIG. 5.

(Color online) (a) Time development of the average and the standard deviation of the cluster-size distribution. The dashed lines represent the simulation data for and with (BD) or 0.0076 (MPC). The top two lines represent the BD data for (upper line) and (lower line); the bottom two lines represent the MPC data. The solid lines are calculated from Eq. (15) with the kernel (17) for nonhydrodynamic (“hy−,” ) and the kernel (16) for hydrodynamic diffusion (“hy+,” ), respectively. The data with hydrodynamics are shifted by a factor of 6 horizontally to avoid an overlap of lines. (b) Time development of the cluster density obtained from BD simulations for the various sizes , as indicated. (c) Cluster-size distributions obtained from BD simulations at various times , as indicated. In the histogram for , data for are smoothed by averaging over some range of neighboring cluster sizes. The solid lines in (b) and (c) represent the cluster densities and size distribution calculated from Eq. (15) with the simulated distribution at as initial condition.

Image of FIG. 6.
FIG. 6.

Snapshot of the S-shaped conformation of a closing membrane for , , and .

Image of FIG. 7.
FIG. 7.

(Color online) Time development of the radius of gyration for the closure of a vesicle from a flat membrane at , , and , as obtained from BD simulations. The lines represent three examples with different realizations of the thermal white noise.

Image of FIG. 8.
FIG. 8.

(Color online) Time development of (a) the radius of gyration , (b) the asphericity , and (c) the attractive energy for vesicle closure with and . The lines represent data of BD for , 4, 5, and 6 (from bottom to top; brown, green, red, and blue). The reference time is set at ; time is rescaled by the dimensionless line tension to reduce the difference in time scales. Error bars are shown at several data points.

Image of FIG. 9.
FIG. 9.

(Color online) Relation of the average asphericity to the normalized radius of gyration during vesicle closure, for membranes of size . (a) Dependence on without hydrodynamic interactions (BD). The solid lines represent data for with , 3, and 6 (from bottom to top; brown, red, and blue). The dashed lines represent data for with , 4, and 6 (from bottom to top; red, green, and blue). [(b) and (c)] Effect of hydrodynamic interactions for . The solid lines (blue) represent the BD results. The dashed (green) and dotted (red) lines represent the MPC data with and 1.3, respectively. In (c), the spherical-cap result, Eq. (21), is given by the dashed line (black) marked “spẖcap.”

Image of FIG. 10.
FIG. 10.

(Color online) Time development of [(a) and (c)] the radius of gyration and (b) the pore angle for vesicle closure with , , and . The angle is calculated from with Eq. (19). The box size in (a) and (b) is . The lines represent MPC data with , 0.34, and 1, as indicated. The time axis is scaled with the characteristic time . The insets in (a) and (b) show the same data, but the time axis now scaled with . The dashed line in the inset of (b) shows the result of Eq. (24) with . The solid and dashed lines in (c) represent data for and , respectively.

Image of FIG. 11.
FIG. 11.

(Color online) (a) Latency time and (b) closure time for a membrane of size . The full lines with symbols represent data of BD for (squares) and (circles). The dashed lines with symbols represent data of MPC for with solvent viscosities (triangles) and 1.9 (diamonds).

Image of FIG. 12.
FIG. 12.

Snapshots of the dissolution process of a vesicle in BD simulation with , , , simulation-box size , at times (a) , (b) , (c) , (d) .

Image of FIG. 13.
FIG. 13.

(Color online) Time development of (a) the radius of gyration and (b) the asphericity of the largest cluster during vesicle dissolution with , , , and box size . The dashed lines represent the same data as in Fig. 12. The solid lines represent the averaged data with the reference time set at . The asphericity is only shown for the largest cluster, and as long as .

Image of FIG. 14.
FIG. 14.

(Color online) Rupture time of a vesicle with and . The circles and squares represent data of BD and MPC, respectively.

Image of FIG. 15.
FIG. 15.

(Color online) Time development of the average number of particles in the first and second largest clusters, for and . (a) BD results for , 1.3, and 1.4, with box size . The dashed lines are fits to Eq. (28). The inset shows the dependence of the decay rate in Eq. (28). (b) The solid lines represent results of BD simulations with , 50, 64, and 100 (from top to bottom) at . The short-dashed (red) line represents results of MPC simulations for and . The long-dashed line (black) is obtained from Eq. (30) with , , and the same decay rate as determined in (a). Error bars are shown at several data points.

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/content/aip/journal/jcp/125/16/10.1063/1.2358983
2006-10-27
2014-04-18
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Dynamics of vesicle self-assembly and dissolution
http://aip.metastore.ingenta.com/content/aip/journal/jcp/125/16/10.1063/1.2358983
10.1063/1.2358983
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