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Three-dimensional Monte Carlo simulations of intracellular diffusion and reaction of signaling proteins
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10.1063/1.2753159
/content/aip/journal/jcp/127/3/10.1063/1.2753159
http://aip.metastore.ingenta.com/content/aip/journal/jcp/127/3/10.1063/1.2753159
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

(Color online) Cross sections of the cell. The white area represents the cytoplasm. The plus signs show the nucleus. Sites 1 or 2 corresponds to the initial location of a protein.

Image of FIG. 2.
FIG. 2.

Distribution of for and . The solid and open circles correspond to the situations when a protein is initially located in site 1 and 2 (Fig. 1), respectively. The solid lines represent the exponential distribution. Panel (a) shows the results for a single gene located in the center of the nucleus. Panels (b) and (c) are for 10 and 100 genes randomly distributed in different sites representing the nucleus. In all these cases, is found to be nearly independent of the initial location of a protein. Specifically, the model predicts (a), (b), and (c).

Image of FIG. 3.
FIG. 3.

As Fig. 2 for the situation when the reaction occurs as soon as a protein reaches a site with a gene. For initial protein locations 1 and 2, the model predicts in this case, respectively: (a) and; (b) and ; (c) and .

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/content/aip/journal/jcp/127/3/10.1063/1.2753159
2007-07-16
2014-04-20
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Three-dimensional Monte Carlo simulations of intracellular diffusion and reaction of signaling proteins
http://aip.metastore.ingenta.com/content/aip/journal/jcp/127/3/10.1063/1.2753159
10.1063/1.2753159
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